equis - Articles
Medetomidine
Introduction
Name
- Medetomidine hydrochloride.
Class of drug
- Alpha-2 adrenergic agonist.
Description
Chemical name
- (RS)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole.
Molecular formula
- C13H16N2.
Molecular weight
- 200.279 g.
Physical properties
- Clear aqueous solution only available as 1 mg/ml concentration.
- Contains preservatives.
Storage requirements
- Protect from light.
- Store below 25°C.
- Do not freeze.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Goodwin W A, Keates H L, Pearson M & Pasloske K (2013) Alfaxalone and medetomidine intravenous infusion to maintain anaesthesia in colts undergoing field castration. Equine Vet J 45 (3), 315-319 PubMed.
- Auckburally A & Flaherty D (2011) Equine supplemental intravenous anaesthesia/analgesia. In Pract.
- Solano A M, Valverde A, Desrochers A, Nykamp S & Boure L P (2010) Behavioural and cardiorespiratory effects of a constant rate infusion of medetomidine and morphine for sedation during standing laparoscopy in horses. Equine Vet J 41 (2), 153-159 PubMed.
- Valverde A et al (2010) Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery. Equine Vet J 42 (3), 192-199 PubMed.
- Bettschart-Wolfensberger R & Larenza M P (2007) Balanced anesthesia in the equine. Clin Techs Equine Pract 6 (2), 104-110.
- Ringer S K et al (2007) A clinical comparison of two anaesthetic protocols using lidocaine or medetomidine in horses. Vet Anaesthesia Analgesia 34 (4), 257-268 PubMed.
- Kalchofner K S et al (2006) Clinical assessment of anesthesia with isoflurane and medetomidine in 300 equidae. Pferdeheilkunde 22 (3), 301.
- Bettschart-Wolfensberger R et al (2003) Medetomidine-ketamine anaesthesia induction followed by medetomidine-propofol in ponies: infusion rates and cardiopulmonary side effects. Equine Vet J 35 (3), 308-313 PubMed.
- Bettschart-Wolfensberger R et al (1999) Pharmacokinetics of medetomidine in ponies and elaboration of a medetomidine infusion regime which provides a constant level of sedation. Res Vet Sci 67 (1), 41-46 PubMed.
- Bettschart-Wolfensberger R et al (1999) Cardiopulmonary effects of a two hour medetomidine infusion and its antagonism by atipamezole in horses and ponies. J Vet Anaesthesia 26, 8-12.