equis - Articles
Propofol
Introduction
Name
- Propofol.
Class of drug
- Non-barbiturate alkylphenol.
- General anesthetic agent.
Description
Chemical name
- 2,6 diisopropylphenol.
Molecular formula
- C12H18O.
Molecular weight
- 178.271 g.
Physical properties
- Lipid emulsion.
- 10% soyabean oil.
- 2.25% glycerol.
- 1.2% egg lecithin.
- Preservatives - EDTA; sodium metabisulphite; benzyl alcohol - depending on formulation.
- PropoClear - lipid-free nano-droplet microemulsion withdrawn from market in 2011 due to pain on injection, necrosis and sloughing of skin.
Storage requirements
- Store below 25°C.
- Do not freeze.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Rezende M L, Boscan P, Stanley S D, Mama K R & Steffey E P (2010) Evaluation of cardiovascular, respiratory and biochemical effects, and anesthetic induction and recovery behavior in horses anesthetized with a 5% micellar microemulsion propofol formulation. Vet Anaesth Analg 37 (5), 440-450 PubMed.
- Brosnan R J & Steffey E P (2009) Sedative effects of propofol in horses. Vet Anaesth Analg 36 (5), 421-425 PubMed.
- Muir W W, Lerche P & Erichson D (2009) Anaesthetic and cardiorespiratory effects of propofol at 10% for induction and 1% for maintenance of anaesthesia in horses. Equine Vet J 41 (6), 578-585 PubMed.
- Steffey E P, Brosnan R J, Galuppo L D et al (2009) Use of propofol-xylazine and the Anderson Sling Suspension System for recovery of horses from desflurane anesthesia. Vet Surg 38 (8), 927-933 PubMed.