Overview

• Glutamate dehydrogenase (GDH) is a mitochondrial enzyme that is found predominantly in the liver, kidney and heart muscle.
• GDH is found to a lesser extent in brain, skeletal muscle and leukocytes.
• GDH is found at a higher concentration within the liver so an increase in blood levels are likely to be related to hepatic damage.
• The enzyme is more concentrated within the centrilobular cells within the liver, therefore an increase in GDH implied centrilobular hepatic injury.
• Increased serum GDH is indicative of damaged or necrotic hepatocytes due to liver disease.

Sampling

Tests

Methodologies

• Enzymatic method involving oxidation of NADH.

Availability

• Variable.

Result Data

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Lindena J & Trautschold I (1986) Catalytic enzyme activity concentration in plasma of man, sheep, dog, cat, rabbit, guinea pig, rat and mouse. Approach to a quantitative diagnostic enzymology, I. Communication. J Clin Chem Clin Biochem 24 (1), 11-18 PubMed.

Other sources of information

• McLaughlin R M & Fish R E (1994) Clinical Biochemistry and Haematology. In: The Biology of the Laboratory Rabbit. 2nd edn. Eds: Manning P J, Ringler D H & Newcomber C E. Academic Press, UK. pp 115.
• Wesche P (2014) Clinical Pathology. In: BSAVA Manual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA, UK. pp 124-137.
• Mark A et al (2012) The Laboratory Rabbit, Guinea Pig, Hamster and other Rodents. 1st edn. Elsevier, London, UK.