Introduction

Name

• Terbinafine.

Class of drug

• Allylamine antifungal agent.

Description

Chemical name

• (E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine hydrochloride.

Molecular formula

• C₂₁H₂₆ClN.

Molecular weight

• 327.9 g/mol.

Storage requirements

• This medicinal product does not require any special storage conditions.

Uses

Indications

• Treatment of dermatophytosis in rabbits Ringworm.

• Terbinafine is highly efficacious against the Microsporum canis Microsporum canis, M. gypseum and Trichophyton mentagrophytes Trichophyton spp, with a reported minimum inhibitory concentration (MIC) of 0.03 µg/mL.
• In rabbits, experimentally infected with aspergillosis and coccidiomycosis, terbinafine administered at 100 or 200 mg/kg PO q24h had no significant effect on disease progression.

Administration

Pharmacokinetics

Precautions

Interactions

With other drugs

• Fewer potential drug interactions than ketoconazole as does not inhibit cytochrome P450 system.
• Rifampicin:
  • Plasma concentrations of terbinafine decreased.
  • Rifampicin increased the clearance of terbinafine by 100% (human datasheet).
• Cimetidine:
  • Plasma concentrations of terbinafine increased.
  • Cimetidine Cimetidine decreased the clearance of terbinafine by 30% (human datasheet).

Adverse Reactions

Further Reading

Publications

Refereed Papers

• Recent references from PubMed and VetMedResource.
• Hawkins M G (2014) Advances in exotic mammal clinical therapeutics. J Exotic Pet Med 23 (1), 39-49 VetMedReource.
• Bourguet A, Guyonnet A, Donzel E et al (2014) Keratomycosis in a pet rabbit (Oryctolagus cuniculus) treated with topical 1% terbinafine ointment. Vet Ophthal 19 (6), 504-509 PubMed.
• Keller K A (2012) Therapeutic review: terbinafine. J Exotic Pet Med 21, 181-185 ResearchGate.
• Kirkpatrick W R, Vallor A C, McAtee R K et al (2005) Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. Antimicrob Agents Chemother 49 (11), 4751-4753 PubMed.
• Sorensen K N, Sobel R A, Clemons K V et al (2000) Comparative efficacies of terbinafine and fluconazole in treatment of experimental coccidioidal meningitis in a rabbit model. Antimicrob Agents Chemother 44 (11), 3087-3091 PubMed.

Other sources of information

• Morrisey J K & Carpenter J W (2021) Appendix: Formulary. In: Ferrets, Rabbits and Rodents Clinical Medicine and Surgery. 4th edn. Eds: Quesenberry K E, Orcutt C J, Mans C & Carpenter J W. Elsevier, USA. pp 620-630.
• Hedley J (2020)  Ed. BSAVA  Small Animal Formulary, Part B: Exotic Pets.  10th edn.  BSAVA, UK.
• PubChem (2015) Compound Summary Terbinafine Hydrochloride.  National Center for Biotechnology Information, USA. Website: www.pubchem.ncbi.nlm.nih.gov.

Organisation(s)

• National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.