ISSN 2398-2969      

Sevoflurane

Clapis

Synonym(s): Sevo, Fluoromethyl


Introduction

Name

  • Sevoflurane.

Class of drug

  • Halogenated inhalation anesthetic drug.
     

Description

Chemical name

  • Fluoromethyl 2,2,2-trifluoro-l-(trifluoromethyl)ethyl ether.

Molecular formula

  • C4H3F7O.

Molecular weight

  • 200.05.

Physical properties

  • Clear, colorless non-pungent volatile liquid (isopropyl ether).
  • Boiling point 58.5°C, saturated vapor. 
  • Blood-gas partition coefficient of 0.7.
  • Pressure at 20°C of 160 mmHg.

Storage requirements

  • Store in manufacturers' amber colored bottles.
  • Store at room temperature (15-30°C).

Uses

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Indications

  • Approved for the induction and maintenance of anesthesia in dogs.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Prolongs the effects of neuromuscular blocking agents.

Interacts with desiccated carbon dioxide (soda lime and barium hydroxide lime) absorbents to produce carbon monoxide and Compound A.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references to PubMed and VetMedResource.
  • Yin Y, Yan M & Zhu T (2012) Minimum alveolar concentration of sevoflurane in rabbits with liver fibrosis. Anesth Analg 114 (3), 561-565 PubMed.
  • Branson K R, Quandt J E, Martinez E A et al (2001) A multisite case report on the clinical use of sevoflurane in dogs. J Am Anim Hosp Assoc 37 (5), 420-432 PubMed.
  • Takeda T, Makita K, Ishikawa S et al (2000) Uptake and elimination of sevoflurane in rabbit tissues--an in vivo magnetic resonance spectroscopy study. Can J Anaesth 47 (6), 579-584 PubMed.
  • Clarke K W (1999) Desflurane and sevofurane. New volatile anesthetic agents. Vet Clin North Am Small Anim Pract 29 (3), 793-810 PubMed.
  • Flecknell P A, Roughan J V & Hedenqvist P (1999) Induction of anaesthesia with sevoflurane and isoflurane in the rabbit. Lab Anim 33 (1), 41-46 PubMed.
  • Johnson R A, Striler E, Sawyer D C et al (1998) Comparison of isoflurane with sevoflurane for anesthesia induction and recovery in adult dogs. Am J Vet Res 59 (4), 478-481 PubMed.
  • Mutoh T, Nishimura R, Kim H Y et al (1997) Cardiopulmonary effects of sevoflurane, compared with halothane, enflurane, and isoflurane, in dogs. Am J Vet Res 58 (8), 885-890 PubMed.
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