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Doramectin
Introduction
Name
- Doramectin.
Class of drug
- A semisynthetic member of the avermectin class, structurally similar to abamectin and ivermectin.
- An ecto- and endoparasiticide.
Description
Chemical name
- 25-cyclohexyl-5-O-demethyl-25-de(l-methylpropyl)avermectin A1a.
Molecular formula
- C50H74O14.
Molecular weight
- 899.1 g/mol.
Physical properties
- Solution licensed for injection for cattle and sheep is clear, colorless, to pale yellow oily solution for parenteral administration.
Storage requirements
- Do not store above 30°C/86°F.
- Do not freeze.
- Do not refrigerate.
- Protect from direct sunlight.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
- Elhawary N M, Sorour S S G H, El-Abasy M A, Bazh E K & Sultan K (2017) A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite "Psoroptes cuniculi". Pol J Vet Sci 20 (3), 521-525 PubMed.
- Santos R R D, Coelho C N, Nunes T A et al (2017) Efficacy of oral doramectin as treatment for Psoroptes ovis and Leporacarus gibbus in naturally infested rabbits. Pesquisa Veterinária Brasileira 37 (1), 47-51 Scielo (pdf download).
- Bulliot C, Mentre V, Marginac G, Polock B & Chermette R (2013) A case of atypical psoroptic mange in a domestic rabbit. J Exotic Pet Med 22 (4), 400-404 VetMedResource.
- Doan H T T, Noh J H, Kim Y H, Yoo M S et al (2013) The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea. Vet Parasitol 198 (3-4), 406-409 PubMed.
- Gokbulut C, Biligili A, Kart A & Turgut C (2010) Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits. Lab Anim 44 (2), 138-142 PubMed.
- Kaya D, Inceboz T & Kolatan E et al (2010) Comparison of efficacy of ivermectin and doramectin against mange mite (Sarcoptes scabiei) in naturally infested rabbits in Turkey. Vet Ital 46 (1), 51-56 PubMed.
- Bian Y, Yang G, Wang T & Yan H et al (2009) Haemaphysalis concinna (Acari: Ixodida): Persistent efficacy of doramectin in rabbits under laboratory conditions. Entomol Res 39 (2), 119-122 WileyOnline.
- Li N, Jiang H, Li J, Wang Z et al (2009) Pharmacokinetics of doramectin in rabbits after subcutaneous administration. J Vet Pharmacol Therapeut 32 (4), 397-399 WileyOnline.
- Shen J, Li N, Jiang H, Li J et al (2009) Residue depletion of doramectin in rabbit tissues after SC administration. J Food Prot 72 (10), 2189-2194 PubMed.
- Jiang H, Zhou D, Li H, Xu F, Li C, Shen J, Li X & Ding S (2008) LC-fluorescence detection of abamectin, ivermectin, doramectin, and eprinomectin in rabbit feces. Chromatographia 68 (3), 259-262 AGRIS.
- Kanbur M, Atalay O, Ica A, Eraslan G & Cam Y (2008) The curative and antioxidative efficiency of doramectin and doramectin+vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits. Res Vet Sci 85 (2), 291-293 PubMed.
- Voyvoda H, Ulutas B, Eren H, Karagenc T & Bayramli G (2005) Use of doramectin for treatment of sarcoptic mange in five Angora rabbits. Vet Derm 16 (4), 285-288 PubMed.
Other sources of information
- PubChem (online) Compound Summary Doramectin. In: National Center for Biotechnology Information. Website: pubchem.ncbi.nlm.nih.gov.