ISSN 2398-2969      

Doramectin

Clapis
Contributor(s):

Sarah Pellett

Anna Meredith


Introduction

Name

  • Doramectin.

Class of drug

  • A semisynthetic member of the avermectin class, structurally similar to abamectin and ivermectin.
  • An ecto- and endoparasiticide.

Description

Chemical name

  • 25-cyclohexyl-5-O-demethyl-25-de(l-methylpropyl)avermectin A1a.

Molecular formula

  • C50H74O14.

Molecular weight

  • 899.1 g/mol.

Physical properties

  • Solution licensed for injection for cattle and sheep is clear, colorless, to pale yellow oily solution for parenteral administration.

Storage requirements

  • Do not store above 30°C/86°F.
  • Do not freeze.
  • Do not refrigerate.
  • Protect from direct sunlight.

Uses

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Indications

  • Doramectin is not licensed for use in the rabbit, but several publications discuss the use of doramectin for mites and ticks in rabbits.

Treatment of Psoroptes cuniculi mites

  • Drugs shown to be effective against Psoroptes cuniculi Psoroptes cuniculi are ivermectin Ivermectin, selamectin Selamectin, moxidectin Moxidectin and doramectin.
  • In one study, rabbits with Psoroptes infestation that were treated subcutaneously with doramectin at a single dose of 200 μg/kg BW showed a very low therapeutic effect, although there was significant improvement when the dose was doubled to 400 μg/kg BW, with the number of mites counted decreasing significantly. Other agents were more valuable, showing that ivermectin Ivermectin spot-on applied locally on infested ears proved to be more effective against P. cuniculi than doramectin administered via the SC route.

Treatment of sarcoptic mange

  • In one study, five Angora rabbits naturally infested with Sarcoptes scabiei Sarcoptes scabiei first received two subcutaneous injections 10 days apart of moxidectin 1% injectable solution at a dosage of 0.2 mg/kg BW:
    • This resulted in clinical improvement initially, but on days 10 and 35 post-initial treatment live mites were observed in skin scrapings.
    • Doramectin 1% was then administered via SC injections 10 days apart and led to complete resolution of clinical signs and parasitological cure in all 5 rabbits.
  • In another study, 14 New Zealand rabbits with Sarcoptes scabiei Sarcoptes scabiei infestation were split into three groups: those with low, medium and high intensity of infestation:
    • Within these 3 groups, the rabbits were divided again, some being treated with ivermectin, and the others given doramectin using the same dose and time intervals.
    • By day 28 after starting the treatment, the rabbits with low and medium intensity had recovered with administration of both doramectin and ivermectin.
    • In the high intensity infestation groups, both drugs were efficacious microscopically and macroscopically, however ivermectin had a more rapid effect than doramectin.

Treatment of Leporacarus gibbus

  • One study evaluated the efficacy of a single oral dose of doramectin in the control of Psoroptes ovis and Leporacarus gibbus Leporacarus gibbus in naturally infested rabbits.
  • Sixteen adult rabbits were selected and were put in two experimental groups:
    • The treated group received 200 μg/kg of oral doramectin (control group received the same volume of saline solution).
    • An efficacy of 75% and 87.5% was observed for L. gibbus in days +3 and +7 after treatment. After 14 days post treatment there was 100% efficacy.
    • An efficacy of 100% for the control of P. ovis was observed after 7 days.
    • No adverse effects were observed in any of the rabbits administered doramectin.

Treatment/control of ticks

  • In one study, the efficacy of a single subcutaneous injection of an avermectin (ivermectin, doramectin, or abamectin) as a treatment for experimental infestation with nymphal and adult Haemaphysalis longicornis was assessed in 24 New Zealand White rabbits.
  • Rabbits were injected with commercial injectable formulations of the avermectin (1%) assigned to their treatment group, at a single dose of 200 μg/kg via the SC route.
  • Nymphs and female ticks had significantly reduced weight, nymphs had reduced molting success rates, and female ticks had inhibited ovary development.
  • Of the three treatment agents, doramectin was most effective in reducing the weight of nymphs (weight was reduced by 80%) and females (by 97.3%).
  • Both doramectin and abamectin were effective in inhibiting the development of female ticks’ ovaries (by 46%).

Administration

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Pharmacokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Interactions

with other drugs

  • None known.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Elhawary N M, Sorour S S G H, El-Abasy M A, Bazh E K & Sultan K (2017) A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite "Psoroptes cuniculi". Pol J Vet Sci 20 (3), 521-525 PubMed.
  • Santos R R D, Coelho C N, Nunes T A et al (2017) Efficacy of oral doramectin as treatment for Psoroptes ovis and Leporacarus gibbus in naturally infested rabbits. Pesquisa Veterinária Brasileira 37 (1), 47-51 Scielo (pdf download).
  • Bulliot C, Mentre V, Marginac G, Polock B & Chermette R (2013) A case of atypical psoroptic mange in a domestic rabbit. J Exotic Pet Med 22 (4), 400-404 VetMedResource.
  • Doan H T T, Noh J H, Kim Y H, Yoo M S et al (2013) The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea. Vet Parasitol 198 (3-4), 406-409 PubMed.
  • Gokbulut C, Biligili A, Kart A & Turgut C (2010) Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits. Lab Anim 44 (2), 138-142 PubMed.
  • Kaya D, Inceboz T & Kolatan E et al (2010) Comparison of efficacy of ivermectin and doramectin against mange mite (Sarcoptes scabiei) in naturally infested rabbits in Turkey. Vet Ital 46 (1), 51-56 PubMed.
  • Bian Y, Yang G, Wang T & Yan H et al (2009) Haemaphysalis concinna (Acari: Ixodida): Persistent efficacy of doramectin in rabbits under laboratory conditions. Entomol Res 39 (2), 119-122 WileyOnline.
  • Li N, Jiang H, Li J, Wang Z et al (2009) Pharmacokinetics of doramectin in rabbits after subcutaneous administration. J Vet Pharmacol Therapeut 32 (4), 397-399 WileyOnline.
  • Shen J, Li N, Jiang H, Li J et al (2009) Residue depletion of doramectin in rabbit tissues after SC administration. J Food Prot 72 (10), 2189-2194 PubMed.
  • Jiang H, Zhou D, Li H, Xu F, Li C, Shen J, Li X & Ding S (2008) LC-fluorescence detection of abamectin, ivermectin, doramectin, and eprinomectin in rabbit feces. Chromatographia 68 (3), 259-262 AGRIS.
  • Kanbur M, Atalay O, Ica A, Eraslan G & Cam Y (2008) The curative and antioxidative efficiency of doramectin and doramectin+vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits. Res Vet Sci 85 (2), 291-293 PubMed.
  • Voyvoda H, Ulutas B, Eren H, Karagenc T & Bayramli G (2005) Use of doramectin for treatment of sarcoptic mange in five Angora rabbits. Vet Derm 16 (4), 285-288 PubMed

Other sources of information

  • PubChem (online) Compound Summary Doramectin. In: National Center for Biotechnology Information. Website: pubchem.ncbi.nlm.nih.gov.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code