ISSN 2398-2969      

Dexamethasone

Clapis
Contributor(s):

Ron Rees Davies


Introduction

Name

  • Dexamethasone.

Class of drug

Uses

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Indications

  • High-dose therapy in conditions where water retention would be a disadvantage.
  • Anti-inflammatory potency 7.5x prednisolone.
  • Not suitable for alternate day use because of long duration of action.
  • Anti-inflammatory drug.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Amphotericin B or potassium-depleting diuretics (furosemide, thiazides)

Insulin

  • May antagonize effects of insulin.

Phenobarbital or phenytoin

  • These drugs may accelerate the metabolism of glucocorticoids.

Non-steroidal inflammatory drugs

  • Increased risk of gastrointestinal ulceration if used concurrently.

with diagnostic tests

Urine glucose levels
  • May be increased.

Liver

  • Elevated liver enzymes.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Exotic Animal Formulary. Carpenter JW, Mashima TY and Rupiper DJ (2001) 2nd edn. Saunders, Philadelphia. ISBN: 0-7216-8312-6.
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