ISSN 2398-2969      

Deslorelin

Clapis

Synonym(s): Suprelorin


Introduction

Name

  • Deslorelin.
  • Available veterinary formulation contains deslorelin as deslorelin acetate.

Class of drug

  • Gonadotrophin-releasing hormone (GnRH) agonist.

Description

Chemical name

  • acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide.

Molecular formula

  • C66H87N17O14.

Molecular weight

  • 1342.5 g/mol.

Physical properties

  • White to pale yellow cylindrical implant (size of a microchip).
  • Implant is supplied in a pre-loaded implanter.

Storage requirements

  • Store in refrigerator (2-8°C/35.6-46.4°F).
  • Do not freeze.
  • Shelf-life of product packaged for sale: 3 years.

Uses

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Indications

  • Deslorelin implants have been used to manage clinical signs of adrenocortical disease in both male and female rabbits where adrenalectomy was not an option.
  • Non-surgical contraceptive methods are limited in rabbits:
    • In one study it was concluded that application of a deslorelin implant in male rabbits is not a reliable contraceptive method.
    • In another study it showed that deslorelin could suppress estrus in female rabbits, however, over half of the rabbits that received an implant developed uterine pathology.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • None known.

Warnings for personnel handling the product

  • Women in childbearing age should avoid contact with the product or wear disposable plastic gloves when handling the product.
  • ​Pregnant women should handle the product with extreme care.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Wright T, Eshar D, Rooney T & Berle E C-P (2022) Use of a deslorelin implant for management of hyperandrogenism associated with excessive sex hormone production in a female spayed pet rabbit (Oryctolagus cuniculus). J Exotic Pet Med 40, 12-15 SciDirect.
  • Schoemaker N J (2018) Gonadotrophin-releasing hormone agonists and other contraceptive medications in exotic companion animals. Vet Clin Exot Anim 21 (2), 443-464 PubMed.
  • Geyer A, Daub L, Otzdorff C et al (2016) Reversible estrous cycle suppression in prepubertal female rabbits treated with slow-release deslorelin implants. Theriogenol 85 (2), 282-287 PubMed.
  • Geyer A, Poth T, Otzdorff C et al (2016) Histopathological examination of the genital tract in rabbits treated once or twice with a slow-release deslorelin implant for reversible suppression of ovarian function. Theriogenol 86 (9), 2281-2289 PubMed.
  • Rose J B, Vergneau-Grosset C, Steffey M A et al (2016) Adrenalectomy and nephrectomy in a rabbit (Oryctolagus cuniculus) with adrenocortical carcinoma and renal and ureteral transitional cell carcinoma. J Exotic Pet Med 25 (4), 332-341 SciDirect.
  • Goericke-Pesch S, Groeger G, Wehrend A (2015) The effects of a slow release GnRH agonist implant in male rabbits. Anim Repro Sci 152, 83-89 PubMed.
  • Risi E (2014) Control of reproduction in ferrets, rabbits and rodents. 49 (Suppl 2), 81-86 PubMed.
  • Johnson J G (2013) Therapeutic review: Deslorelin acetate subcutaneous implant. J Exotic Pet Med 22, 82-84.

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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