ISSN 2398-2969      

Cimetidine

Clapis
Contributor(s):

Introduction

Name

  • Cimetidine.

Class of drug

  • H2-antihistamine.

Description

Chemical name

  • N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine.

Molecular formula

  • C10H16N6S.

Physical properties

  • Tablets.

Storage requirements

  • In a dry environment.

Uses

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Indications

  • Gastric and duodenal ulcers.
  • Uremic gastritis.
  • Stress or drug-related erosive gastritis.
  • Esophagitis.
  • Hypersecretory conditions secondary to gastrinoma or mastocytosis.
  • Adjunctively to reverse metabolic alkalosis .
  • May be useful as an immunomodulating agent by preventing activation of suppressor T cells by histamine although evidence is lacking.

Administration

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Precautions

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Interactions

with other drugs

Drugs affected by cimetidine (increased plasma levels)
  • Beta-blockers, eg propranolol .
  • Calcium channel blockers, eg verapamil.
  • Diazepam   Diazepam  .
  • Lignocaine   Lidocaine  .
  • Metronidazole   Medetomidine  .
  • Pethidine   Pethidine  .
  • Phenytoin.
  • Quinidine.
  • Theophylline.
  • Warfarin.
  • Phenobarbital.

Sucralfate

  • Sucralfate may reduce bioavailability of H2 antagonists.
  • Whilst there is little evidence to suggest that this is clinically significant it may be wise to administer sucralfate at least 30 minutes before cimetidine.

Antacids, digoxin, ketoconazole, metoclopropamide

  • Stagger oral doses of cimetidine when used with these drugs   Metoclopramide  by 2 hours.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
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