Introduction

Name

• Carprofen.

Class of drug

• Non-steroidal anti-inflammatory (NSAID)   Therapeutics: non-steroidal anti-inflammatory drugs  .

Description

Chemical name

• (RS)-2-(6-Chloro-9H-carbazol-2-yl)propanoic acid.

Molecular formula

• C15H12ClNO2.

Molecular weight

• 273.71.

Uses

Indications

• Pain control and reduction of inflammation.
• Analgesic activity enhanced if used pre-emptively.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• Carprofen is highly protein-bound and may displace other protein-bound drugs, thereby increasing the risk of toxicity.

Nephrotoxic agents

• Avoid the concurrent use of NSAIDs with other potentially nephrotoxic agents, eg aminoglycosides.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Tomlinson J & Blikslager A (2003) Role of non-steroidal anti-inflammtory drugs in gastrointestinal tract injury and repair. JAVMA 222 (7), 946-951 PubMed.
• Issacs J P (1999) Carpofen. Comp Contin Educ Pract Vet 21 (3), 246-248 Link Opens in New Tab.

Other sources of information

• Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
• Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website:www.gov.uk/government/collections/veterinary-medicines-guidance-notes-vmgns.
• Pfizer, Inc. (2002) Five-year safety profile for Rimadyl (Carprofen).

Organisation(s)

• National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website:  www.noahcompendium.co.uk/Compendium/Overview/-21789.html .