ISSN 2398-2969      

Lymphosarcoma: overview

Clapis

Synonym(s): Malignant lymphoma, lymphoma


Classification

  • Lymphoma/lymphosarcoma is a neoplastic process defined by an atypical proliferation of malignant lymphocytes in solid organs for example the lymph nodes, spleen, liver and bone marrow. 
  • Abnormal lymphocytes may also invade the gastrointestinal tract, the eye and the skin, causing disease in these areas. 
  • Lymphoma/lymphosarcoma is the most common neoplasia seen in young rabbits and the second most common neoplasia overall. 
  • Lymphosarcomas may be either B-lymphocyte or T-lymphocyte in origin. It may be classified as either low or high grade depending on the degree of signs of malignancy and spread.
  • Lymphoma may be described as lymphoblastic (large cell) or lymphocytic (small cell).

Signs and symptoms

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Diagnosis

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Treatment

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Prognosis

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • van Zeeland Y (2017) Rabbit oncology: diseases, diagnostics and therapeutics. Vet Clin Exot Anim 20 (1), 135-182 PubMed.
  • von Bomhard W, Goldschmidt M H, Shofer F S et al (2007) Cutaneous neoplasms in pet rabbits: a retrospective study. Vet Pathol 44 (5), 579-88 PubMed.
  • Graham J E, Kent M S, Théon A (2004) Current therapies in exotic animal oncology. Vet Clin Exot Anim (3), 757-781 PubMed.
  • Kent M S (2004) The use of chemotherapy in exotic animals. Vet Clin Exot Anim (3), 807-820 PubMed.
  • Mehler S J & Bennett R A (2004) Surgical oncology of exotic animals. Vet Clin Exot Anim (3), 783-805 PubMed.
  • Heatley J & Smith A N (2004) Spontaneous neoplasms of lagomorphs. Vet Clin Exot Anim 7 (3), 561-577 PubMed.
  • Gomez L, Gasquez A, Roncero V et al (2002) Lymphoma in a rabbit: histopathological and immunohistochemical findings. J Small Anim Pract 43 (5), 224-226 PubMed.
  • White S D, Campbell T, Logan A et al (2000) Lymphoma with cutaneous involvement in three domestic rabbits (Oryctolagus cuniculus). Vet Derm 11 (1), 61-67 VetMedResource.
  • Shibuya K, Tajima M, Kanai K et al (1999) Spontaneous lymphoma in a Japanese white rabbit. J Vet Med Sci 61 (12), 1327-1329 PubMed.

Other sources of information

  • Di Girolamo N & Selleri P (2021) Disorders of the urinary and reproductive systems. In: Ferrets, Rabbits, and Rodents. Clinical Medicine and Surgery. 4th edn. Eds: Quesenberry K E, Orcutt C J, Mans C & Carpenter J W. Elsevier, USA. pp 201-219.
  • Varga M (2014) Neoplasia. In: BSAVA manual of rabbit medicine. Eds: Meredith A & Lord B. BSAVA, UK. pp 264-273.
  • Robat C & Mayer J (2013) Lymphosarcoma. In: Clinical Veterinary Advisor. Birds and Exotic Pets. Elsevier, USA. pp 395-396.

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