Overview

• Prolongation of coagulation time absence of or abnormal forms of vitamin-K dependent Factors II, VII and X.

Sampling

Tests

Methodologies

• Kit test that is suitable for standard fibrometer or some automated instruments.

Availability

• Available from some commercial laboratories and/or in-practice testing laboratories.
• Check with commercial laboratories regarding availability.

Validity

Sensitivity

• Test has been validated for use in cats.
• May be more sensitive than PT and/or APTT for detection of absence or antagonism of Vitamin K dependent factors II, VII, and X.

Specificity

• Not specific for underlying cause of Vitamin K absence or antagonism.

Technique (intrinsic) limitations

• See quality control factors listed above.

Result Data

Further Reading

Publications

Refereed papers

• Recent references from VetMedResource and PubMed.
• Center S A, Warner K, Corbet J, Randolph J E & Erb H N (2000) Proteins invoked by vitamin K absence and clotting times in clinically ill cats. JVIM 14 (3), 292-297.

Other sources of information

• Rozanski E A, Drobatz K J, Hughes D, Scottie M & Giger U (1998) Thrombotest (PIVKA), Prothrombin Time and Activated Thromboplastin Time Results in 25 Dogs with Acquired and Hereditary Coagulopathies. In: Proceedings 16th Annual ACVIM Forum. San Diego, CA, USA. Abstract No. 183.