ISSN 2398-2950      

Sarolaner

ffelis

Synonym(s): Revolution Plus™, Stronghold Plus®


Introduction

Name

  • S-enantiomer of sarolaner (Revolution Plus™, Stronghold Plus®)
  • Selamectin Selamectin.

Class of drug

  • Sarolaner is a systemic acaricide and insecticide belonging to the isoxazoline family.

Description

Chemical name

  • 1-(5’-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’-H-spiro(azetidine-3,1’-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone.

Molecular formula

  • C23H18Cl2F4N2O5S

Molecular weight

  • 581.4 g/mol.

Physical properties

  • Clear, colourless to yellow solution for spot-on application.

Storage requirements

  • Store below 30°C in the original carton.
  • Do not remove the pipette from the blister until ready to use.
  • Keep out of the sight and reach of children.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

Note: selamectin component treats and prevents flea infestations Ctenocephalides felis and Ctenocephalides canis, treats ear mite infestations Otodectes cynotis, treats biting lice infestations (Felicola subrostratus Felicola subrostratus), treats adult roundworm (Toxocara cati Toxocara cati) and hookworm (Ancylostoma tubaeforme Ancylostoma tubaeforme) infections and prevents heartworm disease (Dirofilaria immitis Dirofilaria immitis).

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

With other drugs

  • None known.
  • Has been used safely in cats treated with commonly prescribed veterinary medications.

 

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Reichard M V, Rugg J J, Thomas J E, Allen K E, Barrett A W, Murray J K, Herrin B H, Beam R A, King V L, Vatta A F (2019) Efficacy of a topical formulation of selamectin plus sarolaner against induced infestations of Amblyomma americanum on cats and prevention of Cytauxzoon felis transmission. Vet Parasitol 270 Suppl 1, S31-S37 PubMed.
  • Vatta A F, Everett W R, Cherni J A, King V L, Rugg D (2019) The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats. Vet Parasitol 270 Suppl 1, S26-S30 PubMed
  •  Vatta A F, Young D R, Everett W R, King V L, Cherni J A, von Reitzenstein M, Holzmer S J, Chapin S, Rugg D (2019) Efficacy of a new topical formulation containing selamectin plus sarolaner against three common tick species infesting cats in the United States. Vet Parasitol 270 Suppl 1, S19-S25 PubMed.
  • Vatta A F, Young D R, King V L, Myers M R (2019) Comparative efficacy of topical treatments with Revolution® Plus (selamectin and sarolaner) and Bravecto® for Cats (fluralaner) against Ixodes scapularis ticks on cats.Vet Parasitol 270 Suppl 1, S58-S63 PubMed.
  • Yonetake W, Fujii T, Naito M, Hodge A, Maeder S, Rugg D (2019) Efficacy of a new topical formulation of selamectin plus sarolaner for the control of fleas and ticks infesting cats in Japan. Vet Parasitol 270 Suppl 1, S12-S18 PubMed.
  • Becskei C, Lin D, Rugg D, Geurden T (2017) Speed of kill of a new spot-on formulation of selamectin plus sarolaner for cats against induced infestations with Ixodes ricinus. Vet Parasitol 238 Suppl 1, S8-S11 PubMed.
  • Geurden T, Becskei C, Farkas R, Lin D, Rugg D (2017) Efficacy and safety of a new spot-on formulation of selamectin plus sarolaner in the treatment of naturally occurring flea and tick infestations in cats presented as veterinary patients in Europe. Vet Parasitol 238 Suppl 1, S12-S17 PubMed.
  • Geurden T, Becskei C, Vatta AF, Slootmans N, von Reitzenstein M, King V L, Lin D, Rugg D. (2017) Efficacy of a new spot-on formulation of selamectin plus sarolaner against four common tick species infesting cats in Europe. Vet Parasitol 238 Suppl 1, S3-S7 PubMed
  •  Geurden T, Borowski S, Wozniakiewicz M, King V, Fourie J, Liebenberg J (2017) Comparative efficacy of a new spot-on combination product containing selamectin and sarolaner (Stronghold®Plus) versus fluralaner (Bravecto®) against induced infestations with Ixodes ricinus ticks on cats. Parasit Vectors 10, 319 PubMed.

Other sources of information

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code