ISSN 2398-2950      

Leflunomide

ffelis
Contributor(s):

Andrea Tarr

Polly Frowde


Introduction

Name

  • Leflunomide.

Class of drug

  • Immunosuppressant.

Description

Chemical name

  • 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide.

Molecular formula

  • C12H9F3N2O2

Molecular weight

  • 270

Physical properties

  • Occurs as a white or almost white powder. Poorly soluble in water.
  • Available as tablets for oral administration as an authorized human medicine.

Storage requirements

  • Store at room temperature and protect from light.

Uses

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Indications

  • Has been used with methotrexate Methotrexate to treat rheumatoid arthritis Arthritis: rheumatoid in cats.
  • Has been used in dogs to treat immune-mediated blood disorders (eg primary immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, Evans’ syndrome), systemic and cutaneous reactive histiocytosis, immune-mediated polyarthritis and inflammatory rectal polyps. 

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • There may be an increased risk of adverse effects in the case of recent or concomitant use of hepatotoxic or hematotoxic drugs.
  • P450 (CYP) 1A2, 2C19 and 3A4 isoenzymes may be involved in leflunomide metabolism, which may lead to interactions with drugs that affect, or are affected by these isoenzymes.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Tani A et al (2020) Comparison of the efficacy of cyclosporine and leflunomide in treating inflammatory colorectal polyps in miniature dachshunds. Vet Med Sci 82,  4437-4440 PubMed.
  • Weingart C et al (2019) Primary immune-mediated haemolytic anaemia: a retrospective long-term study in 61 dogs. Aus Vet J  97, 483 PubMed.
  • Sato M et al (2017) A retrospective study of the safety and efficacy of leflunomide in dogs. J Vet Intern Med 31, 1502-1507 PubMed.
  • Mehl M L et al (2012) Pharmacokinetics and pharmacodynamics of A771726 and leflunomide in domestic cats. J Vet Pharmacol Ther 35, 139-146 PubMed.
  • Singer L M et al (2011) Leflunomide pharmacokinetics after a single oral administration to dogs. J Vet Pharmacol Ther 34, 609-611 PubMed.
  •  Colopy S A et al (2010) Efficacy of leflunomide for treatment of immune-mediated polyarthritis in dogs: 14 cases (2006–2008). JAVMA 236, 312-318 PubMed.
  • Hanna F Y (2005) Disease modifying treatment for feline rheumatoid arthritis. Vet Comp Orthop Traumatol 18,  94-99 PubMed.

Organisation(s)

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