ISSN 2398-2950      

Erythropoietin

ffelis

Synonym(s): EPO; r-HuEPO


Introduction

Name

  • Erythropoietin.
  • r-Human Erythropoietin.

Class of drug

  • Synthetic hormone.
  • Hemopoietic growth factor.

Description

Chemical name

  • Erythropoietin, epoietin alfa, recombinant human erythropoietin (rHuEPO).

Molecular weight

  • Approximately 30,000.

Physical properties

  • Sterile, colorless solution.

Storage requirements

  • Store in refrigerator at 2-8°C, do not freeze. Do not shake. Single use vial because it contains no preservatives.

Uses

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Indications

  • Treatment of anemia due to chronic renal failure   Kidney: chronic kidney disease  in dogs and cats.
  • Used to treat anemic human patients with cancer and cats with FeLV-associated anemia   Feline leukemia virus disease  .
  • Also reported in the treatment of myelodysplastic syndromes in dogs (Weiss, 2003).
  • Not indicated in conditions where high serum concentrations of the hormone already exist (eg hemolytic anemia, anemia due to blood loss), where anemia is due to iron deficiency or where systemic hypertension is present.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Androgens - may increase sensitivity to EPO.
  • Desmopressin   Desmopressin   - decreased bleeding times.

with diagnostic tests

  • Will increase hematocrit and reticulocyte count.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Roudebush P, Polzin D J, Ross S J, Towell T L, Adams L G & Forrester S D (2009) Therapies for feline chronic kidney disease - What is the evidence? J Fel Med Surg 11, 195-210 PubMed.
  • Langston C E, Reine N J, Kitrell D (2003) The use of erythropoietin. Vet Clin North Am Small Anim Pract 33 (6), 1245-1260 PubMed.
  • Weiss D J (2003) New insights into the physiology and treatment of acquired myelodysplastic syndromes and aplastic pancytopenia. Vet Clin North Am Small Anim Pract 33 (6), 1317-1334 PubMed.
  • Cowgill L D, James K M, Levy J K, Browne J K, Lobingier R T & Egrie J C (1998) Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure. JAVMA 212 (4), 521-528 PubMed.

Other sources of information

  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. pp 349-351. Blackwell Publishing, USA.
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