Introduction

Name

• Emodepside. 

Class of drug

• Anthelmintic. 
• Octadepsipeptide (depsipeptide). 

Description

Chemical name

• N-methylated 24-membered cyclooctadepsipeptide, consisting of 4 alternating residues of N-methyl-L-leucine, 2 residues of D-lactate, and 2 residues of D-phenylacetate. 

Molecular formula

• C₆₀H₉₀N₆O₁₄

Molecular weight

• 1119.4

Physical properties

• Used topically as a spot-on solution and orally as a suspension and as modified-release tablets. Suspension - shake well before use.

Uses

Indications

• Used in combination with praziquantel Praziquantel as a spot-on for cats and as modified-release tablets for dogs for use when there is mixed infection with roundworms and tapeworms.
• Used in combination with praziquantel and tigolaner as a spot-on for cats when there is mixed infection with ectoparasites, roundworms and tapeworms.

Administration

Pharmacokinetics

Precautions

Interactions

With other drugs

• Co-treatment with other drugs that are P-glycoprotein substrates/inhibitors (eg ivermectin and other antiparasitic macrocyclic lactones, erythromycin, prednisolone and cyclosporin) could give rise to pharmacokinetic drug interactions. 

Adverse Reactions

Further Reading

Publications

Refereed Papers

• Recent references from PubMed and VetMedResource.
• Crisi P E, Di Cesare A, Traversa D, Vignoli M, Morelli S, Di Tommaso M, De Santis F, Pampurini F, Schaper R, Boari A (2020) Controlled field study evaluating the clinical efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural cat aelurostrongylosis. Vet Rec 187(5), e34 PubMed.
• Traversa D, Veronesi F, Danesi P, Morelli S, Crisi P E, Morganti G, Iorio R, Pampurini F, Schaper R, Santoro A, Paoletti B, Di Cesare A (2019) Pilot study evaluating the efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural feline troglostrongylosis. Parasit Vectors 12(1), 97 PubMed.
• Böhm C, Petry G, Schaper R, Wolken S, Strube C (2015) Prevention of lactogenic Toxocara cati infections in kittens by application of an emodepside/praziquantel spot-on (Profender®) to the pregnant queen. Parasitol Res 114 Suppl 1, S175-184 PubMed.  
• Böhm C, Wolken S, Schnyder M, Basso W, Deplazes P, Di Cesare A, Deuster K, Schaper R (2015) Efficacy of emodepside/praziquantel spot-on (Profender) against adult Aelurostrongylus abstrusus nematodes in experimentally infected cats. Parasitol Res 114 Suppl 1, S155-164 PubMed. 
• Di Cesare A, Iorio R, Crisi P, Paoletti B, Di Costanzo R, Dimitri C F, Traversa D J (2015) Treatment of Troglostrongylus brevior (Metastrongyloidea, Crenosomatidae) in mixed lungworm infections using spot-on emodepside. J Feline Med Surg 17(2), 181-185 PubMed. 
• Taweethavonsawat P, Chungpivat S, Watanapongchati S, Traub R J, Schaper R (2013) Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender , Bayer) and praziquantel and pyrantel oral tablets (Drontal for Cats) against experimental Ancylostoma ceylanicum infections in cats. Vet Parasitol 191(1-2), 172-176 PubMed. 
• Wolken S, Böhm C, Schaper R, Schnieder T (2012) Treatment of third-stage larvae of Toxocara cati with milbemycin oxime plus praziquantel tablets and emodepside plus praziquantel spot-on formulation in experimentally infected cats. Parasitol Res 111(5), 2123-2127 PubMed.  

Organisation(s)

• European Medicines Agency (2021) Felpreva Positive Opinion: https://www.ema.europa.eu/en/medicines/veterinary/summaries-opinion/felpreva 
• European Medicines Agency (2005) Profender Summary of Product Characteristics: https://www.ema.europa.eu/en/documents/product-information/profender-epar-product-information_en.pdf 
• National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk. 
• VMD Product Information Database: https://www.vmd.defra.gov.uk/ProductInformationDatabase