Introduction

Name

• Amoxicillin.

Class of drug

• Penicillin antibiotic.

Description

Chemical name

• 6[D](-)-a-amino-p-hydroxyphenylacetamido] penicillanic acid.

Physical properties

• Acid-stable, beta-lactamase-susceptible.

Uses

Indications

• Active against certain gram-positive and negative organisms.
• Not active against those that produce penicillinases, eg someE. coli  Escherichia coli  andStaphylococcus aureus  Staphylococcus spp  .
• The more difficult gram-negative organisms (Pseudomonas spp  Pseudomonas spp  andKlebsiella spp) are usually resistant.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

Probenecid

• Will decrease the renal tubular secretion of penicillin antibiotics Penicillamine and thus prolong their blood levels.

Aminoglycosides

• Do not mix in the same syringe as aminoglycosides.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. BSAVA, UK.