ISSN 2398-2950      

Chemotherapy: metronomic

ffelis

Synonym(s): Metronomic chemotherapy, Continuous low dose chemotherapy


Metronomic chemotherapy

  • Differs from traditional chemotherapy in that it is given at a low-dose regular interval, often every 24-48 hours.
It is very important to recognize that the evidence in support of metronomic chemotherapy in veterinary patients is limited. The evidence in feline patients is significantly less than that for their canine counterparts and mainly focuses on hemangiosarcomas and different carcinoma types.

Mechanisms of action

  • Inhibits angiogenesis thus decreasing nutritional support of tumor.
  • Induces endothelial cell apoptosis.
  • Inhibits local proliferation of circulating endothelial cells (CEC) and circulating endothelial precursors (CEP) derived from the bone marrow.
  • Modulates levels of cytokines that increase angiogenesis, eg vascular endothelial growth factor (VEGF) and angiogenesis inhibitor, thrombospondin-1 (TSP-1).
  • Immune modulation: suppression of regulatory T-cells (T-regs) that are involved in the development of tolerance to tumor cells.
  • Direct tumor cell growth inhibition. 
  • Apoptosis induced by NSAIDs Analgesia: NSAID.
  • Possible decreased risk of development of drug resistance due to relative genetic stability of non-tumor target cells.

Toxicities

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Drugs

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Reported uses of metronomic chemotherapy in veterinary patients

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Petrucci G N, Henriques J, Lobo L et al (2020) Adjuvant doxorubicin vs metronomic cyclophosphamide and meloxicam vs surgery alone for cats with mammary carcinomas: A retrospective study of 137 cases. Vet Comp Oncol e12660 doi: 10.1111/vco.12660 PubMed.
  • Marconato L, Weyland M, Tresch N et al (2020) Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment. Vet Comp Oncol 18(3), 362-369 PubMed.   
  • Boland L, Setyo L, Sangster C et al (2019) Colonic malignant peripheral nerve sheath tumour in a cat. JFMS 28 (5) doi: 10.1177/2055116919849979 PubMed.
  • Cheng Y K, Krockenberger M, Bennett P (2018) Use of metronomic chemotherapy in the management of a cat with abdominal haemangiosarcoma. JFMS 10 (4),  PubMed.
  • Biller B (2014) Metronomic chemotherapy in veterinary patients with cancer: rethinking the targets and strategies of chemotherapy. Vet Clin North Am Small Anim Pract 44(5), 817-829 PubMed.  

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code