ISSN 2398-2950      

Myositis ossificans

ffelis
Contributor(s):

Laurent Garosi

Synonym(s): Ossifying myopathy


Introduction

  • Heterotopic ossification in soft tissue/muscle adjacent to bone/periosteum. Localized and generalized forms have been reported.
  • Cause: unknown.
  • Signs: weakness/lameness of affected limb; monoparesis/monoplegia.
  • Treatment: surgical excision.
  • Prognosis: guarded - complete excision often difficult.

Pathogenesis

Etiology

  • Generally unknown.
  • Pathologic findings suggest that this is a disorder of connective tissue affecting primarily the epimysium, tendons, and fasciae, which results in  marked proliferation of fibrovascular connective tissue, with associated chondroid and osseous metaplasia.

Predisposing factors

General

  • Trauma may be associated with localized, ossifying myopathy but it is not a prerequisite.

Pathophysiology

  • Heterotopic ossification of soft tissue adjacent to bone/periosteum.
  • Generalized myositis ossificans results in excessive fibrous connective tissue development causing widespread muscle degeneration and dystrophic calcification and ossification.
  • Lymphocytes may play a role in the pathogenesis of heterotopic ossification in fibrodysplasia ossificans progressiva.
  • 'Tumorous' lesion within muscle   →   weakness/lameness in affected leg.
  • Nerve involvement within pelvis or around hip joint may   →   monoparesis/monoplegia.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Yabuzoe A, Yokoi S, Sekigushi M et al (2009) Fibrodysplasia ossificans progressiva in a Maine Coon cat with prominent ossification in dorsal muscle. J Vet Med Sci 71 (12), 1649-1652 PubMed.
  • Asano K, Sakata A, Shibuya H et al (2006) Fibrodysplasia ossificans progressiva-like condition in cat. J Vet Med Sci 68 (9), 1003-1006 PubMed.
  • Gannon F H, Valentine B A, Shore E M et al (1998) Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressive. Clin Orthop Relat Res (346), 19-25 PubMed.
  • Valentine B A, George C, Randolph J F et al (1992) Fibrodysplasia ossificans progressiva in the cat. A case report. JVIM 6, 335-340 PubMed.
  • Waldron D, Pettigrew V, Turk M et al (1985) Progressive ossifying myositis in a cat. JAVMA 187 (1), 64-65 PubMed.
  • Warren H B, Carpenter J L (1984) Fibrodysplasia ossificans in three cats. Vet Pathol 21 (5), 495-499 PubMed.

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