ISSN 2398-2950      

Myoglobinuria

ffelis
Contributor(s):

Introduction

  • Presence of myoglobin (muscle pigment) in the urine.
  • Cause: myoglobin released from muscle during severe muscle necrosis or trauma.
  • Signs: brownish red urine.
  • Diagnosis: positive occult blood reaction; no erythrocytes in urine sediment.
  • Treatment: treat primary cause of muscle damage, fluid therapy Fluid therapy: overview to support renal function.
  • Prognosis: depends on severity of muscle damage.

Pathogenesis

Etiology

  • Myoglobin released from muscle following:
    • Extensive crushing injuries to muscle.
    • Hyperthermia.
    • Rarely seen in acute polymyositis.
    • Rarely seen associated with degenerative myopathies.
    • Snake envenomation Adder bite poisoning.

Predisposing factors

General

  • Muscle damage.

Pathophysiology

  • Myoglobin enters urine following muscle trauma or necrosis.
  • Myoglobin released from damaged or necrotic muscle   →   binds to plasma proteins   →   excreted in urine before reaching levels that would discolor plasma.
  • Myoglobin is extremely toxic to renal tubules, and myoglobinuria may result in acute renal failure Kidney: acute renal failure.

Timecourse

  • Often acute.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

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