ISSN 2398-2985      

Vitamin K1

Jreptile

Synonym(s): Phytomenadione, Phytonadione, Konakion


Introduction

Name

  • Phytomenadione.

Class of drug

  • Fat-soluble vitamin.

Description

Chemical name

  • 2-methyl-3-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthoquinone.

Molecular formula

  • C31H46O2.

Molecular weight

  • 450.7.

Physical properties

  • Yellow, viscous, odorless oil or crystals.

Storage requirements

  • Stable in air and moisture, but decomposes in sunlight.
  • Store <25ºC/77ºF and protect from light.

Uses

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Indications

  • It is used in the management of vitamin K1 deficiency in patients with liver disease, hypoprothrombinemia secondary to the ingestion of anticoagulant rodenticides, or other vitamin K1-dependent clotting factor abnormalities.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • The effects of the anticoagulants may be enhanced by allopurinol, anabolic steroids, aspirin, chloramphenicol, cimetidine, erythromycin, ketoconazole, metronidazole, phenylbutazone, propranolol, sulfonamides (including trimethoprim-sulfa), and thyroid drugs.
  • The absorption of oral vitamin K is reduced by mineral oil.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Mader D R (2006) Ed. Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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