ISSN 2398-2985      

Vitamin B12

Jreptile

Synonym(s): Cyanocobalamin, Hydroxocobalamin


Introduction

Name

  • Vitamin B12.

Class of drug

  • Water-soluble vitamin.

Description

Chemical name

  • cobalt(3+);[(2R,3S,4R)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,5Z,7S,10Z,12S,13S,15Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl] phosphate;cyanide.

Molecular formula

  • C63H88CoN14O14P.

Molecular weight

  • 1355.38.

Physical properties

  • Dark red crystals or crystalline powder.
  • Sparingly soluble in water and soluble in alcohol.

Storage requirements

  • Cyanocobalamin for injection should be stored below 40ºC/104ºF.
  • Protect from light and freezing.

Uses

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Indications

  • Treatment of vitamin B12 deficiency: malabsorption (gastrointestinal tract disease), gastrointestinal dysbiosis Nutritional requirements.
  • Deficiency of this vitamin has not been properly reported in reptiles.
  • May act as appetite stimulant in snakes and lizards (anecdotal).
  • In veterinary species, cyanocobalamin is the most commonly used form, but hydroxycobalamin is commonly used in humans.

Administration

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Pharmacokinetics

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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