ISSN 2398-2985      

Ivermectin

Jreptile

Synonym(s): Heartgard, Ivomec, Xeno


Introduction

Name

  • Ivermectin.

Class of drug

  • Avermectin.

Description

Chemical name

  • Ivermectin is a mixture containing at least 90% 5-O demethyl-22,23-dihydroavermectin A1a and less than 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro 25-(1-methylethyl)avermectin A1a.

Molecular formula

  • C48H74O14.

Molecular weight

  • 875.

Physical properties

  • Off-white to yellowish powder.
  • Very poorly soluble in water, but soluble in propylene glycol and vegetable oils.

Storage requirements

  • Store at room temperature and protected from light.
  • Ivermectin 1% oral solution is stable at 1:20 and 1:40 dilutions with water for 72 h when stored in a tight container, at room temperature, and protected from light.

Uses

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Indications

  • Management of ectoparasitic and endoparasitic infestations.
  • Not effective for cestodes.
  • Variable effect in pentastomids; these parasites are best removed by surgery or endoscopy.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Do not combine with benzodiazepines (as they also work through GABA potentiation).
  • Use with caution when combined with clarithromycin, cyclosporine, itraconazole, ketoconazole and spironolactone.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Mader D R (2006) Ed. Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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