ISSN 2398-2985      

Doxycycline

Jreptile

Introduction

Name

  • Doxycycline.

Class of drug

  • Lipid-soluble tetracycline antibiotic.

Description

Chemical name

  • (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide.

Molecular formula

  • C22H24N2O8.

Molecular weight

  • 444.44.

Physical properties

  • Available in hyclate, calcium and monohydrate salts.
  • Hyclate: used in the injectable dosage form and in oral tablets and capsules:
    • Also known as doxycycline HCl.
    • Yellow, crystalline powder.
    • Soluble in water and slightly soluble in alcohol.
  • Monohydrate: used in the oral powder for reconstitution:
    • Yellow, crystalline powder.
    • Very slightly soluble in water and sparingly soluble in alcohol.
  • Calcium salt: found in the oral syrup.

Storage requirements

  • Tablets and capsules should be stored in tight, light resistant containers, at room temperature.
  • The hyclate injection, when reconstituted to up to 1 mg/mL may be stored refrigerated for 72 h.
  • Frozen reconstituted solutions (10 mg/mL) are stable for at least 2 months if kept at -20°C/-4°F.
  • If stored at room temperature, they are stable for 12-48 h.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • It is the tetracycline of choice when tetracyclines are indicated.
  • Doxycycline is only moderately effective for most bacteria (gram-negative) commonly involved in reptilian infections; therefore, other antibiotics are recommended as a first line of treatment.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

Antacids, calcium, magnesium and iron salts
  • Absorption of doxycycline reduced.
Phenobarbitone, phenytoin and primidone
  • Increase the metabolism of doxycycline thus decreasing the plasma levels.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Dipineto L, Russo T P, Calabria M et al (2014) Oral flora of Python regius kept as pets. Lett Applied Microbiol 58 (5), 462-465 PubMed.
  • Rinaldi M L (2014) Therapeutic review: doxycycline. J Exotic Pet Med 23 (1), 107-112 VetMedResource.
  • da Silva Sobrinho F B, de Sa M C A, Gouveia G V et al (2017) [Isolation and determination of antimicrobials sensitivity and resistance of bacterial strains present in the cloaca of Trachemys scripta elegans (Wied, 1839) raised in captivity in Petrolina/PE, Brazil]. Pesquisa Veterinaria Brasileira 37 (3), 261-268 VetMedResource.

Other sources of information

  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Saunders, USA.
  • Mader D R (2006) Ed Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
  • McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Blackwell Publishing, UK. pp 579.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

Related Images

Want more related items, why not
contact us

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code