ISSN 2398-2985      

Cimetidine

Jreptile

Introduction

Name

  • Cimetidine.

Class of drug

  • H2 antihistamine.

Description

Chemical name

  • N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine.

Molecular formula

  • C10H16N6S.

Molecular weight

  • 252.34.

Physical properties

  • White to off-white, crystalline powder.
  • Unpleasant odor (subjective).
  • Sparingly soluble in water and soluble in alcohol.
  • Cimetidine HCl occurs as white, crystalline powder and is very soluble in water and soluble in alcohol.

Storage requirements

  • Protected from light and at room temperature.
  • Do not refrigerate injectable product.
  • Oral dosage forms should be stored in tight containers.

Uses

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Indications

  • Gastric and duodenal ulcers.
  • Gastritis.
  • Esophagitis.
  • Gastroesophageal reflux.
  • Adjunctively to reverse metabolic alkalosis.
  • May be used in renal failure to increase phosphate secretion.
  • No scientific studies available to prove or disprove efficacy in reptiles.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Drugs affected by cimetidine (increased plasma levels)
  • Beta-blockers, eg propranolol.
  • Calcium channel blockers, eg verapamil.
  • Diazepam.
  • Lidocaine.
  • Metronidazole.
  • Pethidine.
  • Phenytoin.
  • Quinidine.
  • Theophylline.
  • Warfarin.
  • Phenobarbital.
Sucralfate
  • Sucralfate may reduce bioavailability of H2 antagonists.
  • While there is little evidence to suggest that this is clinically significant it may be wise to administer sucralfate at least 30 min before cimetidine.
Antacids, digoxin, ketoconazole, metoclopropamide
  • Stagger oral doses of cimetidine when used with these drugs by 2 h.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Elsevier Saunders, USA. pp 564.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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