Amikacin
Introduction
Name
- Amikacin.
Class of drug
- Aminoglycoside antibiotic.
Description
Chemical name
- (2S)-4-Amino-N-[(2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5R,6R)-6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxybutanamide.
Molecular formula
- C22H43N5O13.
Molecular weight
- 585.
Physical properties
- White, crystalline powder.
- Sparingly soluble in water.
Storage requirements
- Store at room temperature. Stable for at least 2 years at room temperature.
- Freezing or temperatures above 40°C/104°F should be avoided.
- Solutions may become very pale yellow with time but this does not indicate a loss of potency.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Chung T H, Yi S W, Kim B S et al (2017) Identification and antibiotic resistance profiling of bacterial isolates from septicaemic soft-shelled turtles (Pelodiscus sinensis). Veterinaria Medicina 62 (3), 169-177 VetMedResource.
- Hossain S, Wimalasena S H M P, De Zoysa M et al (2017) Prevalence of Citrobacter spp from pet turtles and their environment. J Exotic Pet Med 26 (1), 7-12 VetMedResource.
- Liu P Y, Weng L L, Tseng S Y et al (2017) Colistin resistance of Pseudomonas aeruginosa isolated from snakes in Taiwan. Can J Infect Dis Med Microbiol [Epub] 7058396 PubMed.
- Rasmussen C, Allender M C, Phillips C A et al (2017) Multi-drug resistance patterns of enteric bacteria in two populations of free-ranging Eastern box turtles (Terrapene carolina carolina). J Zoo Wildlife Med 48 (3), 708-715 PubMed.
- Sykes IV J M, Ramsay E C, Schumacher J et al (2006) Evaluation of an implanted osmotic pump for delivery of amikacin to corn snakes (Elaphe guttata guttata). J Zoo Wildlife Med 37 (3), 373-380 PubMed.
- Johnson J H, Jensen J M, Brumbaugh G W et al (1997) Amikacin pharmacokinetics and the effects of ambient temperature on the dosage regimen in ball pythons (Python regius). J Zoo Wildlife Med 28 (1), 80-88 PubMed.
Other sources of information
- Meredith A (2015) Ed BSAVA Small Animal Formulary 9th edition: Part B - Exotic Pets. BSAVA, UK. pp 195.
- Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Blackwell Publishing, USA. pp 1296.
- Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Elsevier Saunders. USA. pp 564.
- Mader D R (2006) Ed Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
- McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Blackwell Publishing, UK. pp 579.