ISSN 2398-2985      

Gastrointestinal adenocarcinoma / carcinoma

Jreptile
Contributor(s):

Mark Naguib

Vicki Baldrey

Synonym(s): Neuroendocrine gastric adenocarcinoma, Pyloric adenocarcinoma, Pancreatic carcinoma, Intestinal adenocarcinoma, Hepatic carcinoma, Hepatic adenocarcinoma


Introduction

  • Cause: spontaneously occurring gastrointestinal carcinomas and adenocarcinomas are seen in reptiles. Neuroendocrine gastric carcinomas occur spontaneously and are common in Bearded dragons.
  • Signs: anorexia, weight loss, lethargy, hyperglycemia.
  • Diagnosis: endoscopy or exploratory laparotomy and biopsy.
  • Treatment: no known effective treatments.
  • Prognosis: guarded to poor.

Pathogenesis

Pathophysiology

  • Neuroendocrine gastric carcinomas in Bearded dragons arise from the submucosa of the stomach wall, are locally invasive and commonly metastasize to the liver.
  • Neuroendocrine gastric carcinomas produce somatostatin which suppresses insulin production leading to hyperglycemia Hyperglycemia

Timecourse

  • Reptiles hide clinical signs and often present late in the course of disease.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Christman J, Devau M, Wilson-Robles H et al (2017) Oncology of reptiles: Diseases, diagnosis, and treatment. Vet Clin North Am Exotic Anim Prac 20 (1), 87-110 PubMed.
  • Lyons J A, Newman S J, Greenacre C B et al (2010) A gastric neuroendocrine carcinoma expressing somatostatin in a Bearded dragon (Pogona vitticeps). J Vet Diag Invest 22 (2), 316-320 PubMed.
  • Ritter R M, Garner M M, Chilton J A et al (2009) Gastric neuroendocrine carcinomas in Bearded dragons. Vet Pathol 46 (6), 1109-1116 PubMed.

Other sources of information

  • Bruce L S (2011) Gastric Endoneurocrine Carcinoma (Somatostatinoma) in a Bearded Dragon, Pogona vitticeps. In: Proc Assoc Rept Amphibian Vet. pp 149-151 (pdf download).
  • Mauldin G N & Done L B (2006) Oncology. In: Reptile Medicine and Surgery. Ed: Mader D R. Elsevier, USA. pp 581-630.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code