ISSN 2398-2985      

Hematology: lymphocyte

6guinea pig


Overview

  • The appearance of guinea pig lymphocytes may be variable in size, cytoplasmic color and degree of nuclear chromatin condensation.
  • Lymphocytes generally become smaller as they mature.
  • The division between small and large lymphocytes is arbitrary.
  • Mature lymphocytes are the smallest of the white cells. Nucleus is round and evenly stained. Cytoplasm is very sparse and pale blue staining. Cytoplasm may appear as a narrow ring around the nucleus or may even not be evident at all. Large lymphocytes usually have more cytoplasm.
  • Small lymphocytes are considered to be inactive forms.
  • Large lymphocytes that have an increased amount of light-blue cytoplasm and azurophilic granules that vary in size are considered to be T cells.
  • Large lymphocytes of guinea pigs often contain a single large intracytoplasmic inclusion that is referred to as a Kurloff body. Kurloff bodies stain red with Romanowsky stains.
  • The primary function of lymphocytes is immunological, in humoral antibody formation and cell-mediated immunity.

Sampling

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Tests

Methodologies

  • Differential count: results from electronic cell counters should be double-checked with the examination of a stained blood smear.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Campbell T W & Ellis C K (2007) Avian and Exotic Hematology and Cytology. 3rd edn. Wiley-Blackwell. ISBN: 978-0813818115.
  • Fudge A M (1999) Laboratory Medicine. Avian and Exotic Pets. W B Saunders Co. ISBN: 0721 676 790.

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