ISSN 2398-2985      

Blood biochemistry: alanine aminotransferase (SGPT, ALT)

6guinea pig
Contributor(s):

Vetstream Ltd

Molly Varga

Synonym(s): ALT, Serum ALT, SALT, Glutamic-pyruvic transaminase, GPT, Serum GPT, SGPT


Overview

  • Released to serum after damage to, or proliferation of, hepatocytes.
  • Little tissue specificity in the guinea pig. Heart muscle has similar ALT activity to liver.
  • However, do see significant elevations in ALT in conditions of hepatic damage and necrosis.
  • Whilst significant elevations in ALT are noted where there is hepatic damage and necrosis, ALT is neither a specific nor sensitive indicator of hepatocellular injury in the guinea pig.

Sampling

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Tests

Methodologies

  • Varies between laboratories.

Availability

  • Widely available.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Meredith A & Rayment L (2000) Liver disease in rabbits. Sem Avian Exotic Pet Med 9 (3), 146-152.
  • Benson K G & Paul-Murphy J (1999) Clinical pathology of the domestic rabbit: acquisition and interpretation of samples. Vet Clin North Am Exotic Anim Pract 2 (3), 539-552 PubMed.

Other sources of information

  • Varga M (2014) Textbook of Rabbit Medicine. 2nd edn. Butterworth Heinemann Elsevier, UK.
  • Wesche P (2014) Clinical Pathology. In: BSAVA Manual of Rabbit Medicine. Eds: Meredith A & Lord B. pp 124-137. BSAVA, UK.
  • Fudge A M (1999) Laboratory Medicine. Avian and Exotic Pets. W B Saunders Co. ISBN: 0721 676 790.

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