ISSN 2398-2985      

Streptomycin

6guinea pig

Synonym(s): Devomycin


Introduction

Name

  • Streptomycin.

Class of drug

  • Aminoglycoside antibiotic.

Description

Chemical name

  • Streptomycin sulphate: D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1→4)-N,N1-bis(aminoiminomethyl)-,sulfate (2:3) (salt).

Molecular formula

  • C21H39N7O12.

Molecular weight

  • 581.57.

Uses

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Indications

  • An aminoglycoside antibiotic which is active against a wide range of gram-negative and some gram-positive pathogens.
  • Indicated in the treatment of infections caused by organisms sensitive to streptomycin, in particular Leptospirosa spp and Mycobacterium tuberculosis.
  • However, its use is limited because of its ototoxicity.
  • Aminoglycosides require an oxygen rich environment to be effective, thus they are ineffective in low oxygen sites (abscesses, exudates).
  • Not useful to treat brain infections.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Cephalosporins (notably cephalothin)
  • There is an increased risk of nephrotoxicity.
Cytotoxic drugs
  • There is an increased risk of nephrotoxicity.
Cisplatin
  • Ototoxicity is increased.
Loop diuretics
  • Ototoxicity is increased.
Neostigmine and pyridostigmine
  • May be antagonized by aminoglycosides.
Non-depolarizing muscle relaxants, eg tubocurarine
  • Effect may be enhanced by streptomycin.
Penicillin
  • Synergistic action, however, their pharmacokinetics differ, and thus the use of such compound preparations is generally thought to be unjustified.
Beta-lactam antibiotics, eg penicillins, cephalosporins
  • May be inactivated when mixed in vitro.
Heparin
  • May be inactivated when mixed in vitro.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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