ISSN 2398-2985      

Cyclosporin

6guinea pig

Synonym(s): Cyclosporin A, Ciclosporin, Cyclosporine, Atopica, Neoral, Sandimmun, Sigmasporin, Cicloral, Ciclohexal, Colosina, Cysporin, Imusporin


Introduction

Name

  • Ciclosporin.

Class of drug

  • Immunosuppressive agent.

Description

Chemical name

  • [R-[R*,R*-(E)]]-cyclic-(L-alanyl-D-alanyl-N-methyl-L-leucyl­ N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-α -amino­ butyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl).

Molecular formula

  • C62H111N11O12.

Molecular weight

  • 1202.61.

Physical properties

  • White, fine crystalline powder, relatively insoluble in water, but generally soluble in organic solvents and oils.

Storage requirements

  • Each formulation requires different storage conditions.

Uses

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Indications

  • Rarely indicated in guinea pigs.
  • Useful to treat immune-mediated diseases.
  • Chronic recurrent conjunctivitis due to autoimmune disease.
  • Conjuntivitis of the third eyelid.
  • Adjunct in the treatment of corneal ulceration.

Administration

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Interactions

with other drugs

  • Interacts with digoxin Digoxin, azolic antifungals, metoclopramide Metoclopramide and macrolide antibiotics.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK.
  • Carpenter et al (2001) Exotic Animal Formulary. 2nd edn. W B Saunders, USA.
  • Bryn T (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.
  • Bishop Y (1998) The Veterinary Formulary. 4th edn. British Veterinary Association and Royal Pharmaceutical Society.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

Want more related items, why not
contact us

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code