ISSN 2398-2985      

Blood biochemistry: total bilirubin

4ferrets

Synonym(s): Direct and indirect bilirubin, Conjugated and unconjugated bilirubin


Overview

  • Peripheral breakdown of red blood cells and myoglobin → unconjugated (indirect) bilirubin → bound to albumin → transported to liver → conjugated with glucuronic acid (direct bilirubin) → excreted in bile.
  • Unconjugated bilirubin is the most clinically significant fraction because it is the form that is most likely to cause tissue damage.
  • Jaundice, with an increase in total bilirubin, may be primarily due to an increase in direct, or indirect bilirubin or both.
  • Elevations reflect biliary tree disease rather than liver dysfunction.

Sampling

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Tests

Methodologies

  • Van den Bergh method.
  • Measure [total bilirubin] and [direct bilirubin] → [indirect bilirubin] = difference.

Availability

  • Routine test.

Validity

Sensitivity

  • Increased bilirubin level in the ferret is not reliable for significant liver damage and jaundice is found only occasionally.

Specificity

  • Serum bilirubin depends on functionality of liver parenchyma and alteration of the biliary tract.

Technique (intrinsic) limitations

  • Interpret results in conjunction with other laboratory results.

Technician (extrinsic) limitations

  • Routine test.

Result Data

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Vilalta L, Espada Y & Majó N (2016) Liver lobe torsion in a domestic ferret (Mustela putorius furo). Journal of Exotic Pet Medicine 25 (4), 321-326 VetMedResource.
  • Kaye S W, Ossiboff R J, Noonan B et al (2015) Biliary coccidiosis associated with immunosuppressive treatment of pure red cell aplasia in an adult ferret (Mustela putorius furo). Journal of Exotic Pet Medicine 24 (2), 215-222 VetMedResource.
  •  Hein J, Spreyer F, Sauter-Louis C et al (2012) Reference ranges for laboratory parameters in ferrets. Vet Rec 171, 218 PubMed.
  • Hauptman K, Tichy F & Znotek Z (2001) Clinical diagnostics of hepatopathies in small mammals: evaluation of importance of individual methods. Acta Vet Brno 70, 297-311.

Other sources of information

  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code