ISSN 2398-2985      

Blood biochemistry: bile acids

4ferrets

Synonym(s): Bile salts


Overview

  • Bile acids are predominantly made up of cholic acid and chenodeoxycholic acid.
  • Primary bile acids are derived from cholesterol in the liver.
  • Bile acids are conjugated in the liver with taurine or glycine and are excreted in bile via the bile duct as their sodium salts (bile salts).
  • Bile acids are secreted at time of eating to small intestine where they aid in digestion and absorption of fat and fat-soluble vitamins.
  • Bile acids are reabsorbed from the gastrointestinal tract into the circulation.  They are transported to the liver to be re-secreted in the bile.
  • Bile acids are a sensitive indicator of liver function and of integrity of liver, biliary and intestinal circulation.
  • Fasting is particularly important when determining serum bile acids levels.

Sampling

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Tests

Methodologies

  • Enyzmatic (spectrophotometer).
  • Radio-immunoassay (RIA) - uncommon in veterinary laboratories.

Availability

  • Widely available at commercial laboratories.

Validity

Sensitivity

  • In other species it has been sen that sensitivity is increased by performing a bile acid stimulation test.

Specificity

  • In other species, performing a liver biopsy may give more indication of the underlying cause.

Technique (intrinsic) limitations

  • Interpret results in conjunction with other laboratory results (liver enzymes) and/or liver biopsy.

Result Data

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent reference from PubMed and VetMedResource.
  • Hein J, Spreyer F, Sauter-Louis C et al (2012) Reference ranges for laboratory parameters in ferrets. Vet Rec 171, 218.
  • Hauptman K, Tichy F & Znotek Z (2001) Clinical diagnostics of hepatopathies in small mammals: evaluation of importance of individual methods. Acta Vet Brno 70, 297-311.

Other sources of information

  • Eshar D & Mayer J (2013) Bile Acids. In: Clinical Veterinary Advisor Birds and Exotic Pets. Eds: Mayer J & Donnelly T M. Elsevier, USA. pp 606-607.

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code