ISSN 2398-2985      

Terbutaline

4ferrets

Synonym(s): Bricanyl, Monovent, Brethine


Introduction

Name

  • Terbutaline.

Class of drug

  • Beta 2-adrenoceptor agonist.

Description

Chemical name

  • 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol.

Molecular formula

  • C12H19NO3.

Molecular weight

  • 225.28.

Physical properties

  • Slightly bitter-tasting, white to gray-white, crystalline powder.
  • May have a faint odor of acetic acid.
  • One gram is soluble in 1.5 mL of water and 250 mL of alcohol.

Storage requirements

  • Tablets should be stored at room temperature in tight containers.
  • Injection should be stored at room temperature and protected from light. Discolored solutions should not be used.

Uses

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Indications

  • To induce bronchodilation in the treatment of cardiopulmonary disease, including tracheobronchitis, collapsing trachea, pulmonary edema, and allergic bronchitis.
  • To maintain heart rate in animals with sick-sinus syndrome (bradyarrhythmia).

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Theophylline, corticosteroids
  • There is an increased risk of hypokalemia developing if theophylline or high doses of corticosteroids are given with high doses of terbutaline.
Anesthetics (inhalant)
  • Use with inhalation anesthetics may predispose the patient to ventricular arrhythmias, particularly in patients with preexisting cardiac disease (use with caution).
Beta-adrenergic blocking agents
  • May antagonize the effects of terbutaline.
Digoxin
  • Use with digoxin may increase the risk of cardiac arrhythmias.
Monoamine oxidase inhibitors
  • May potentiate the vascular effects of terbutaline.
Other sympathomimetics
  • May increase the risk of developing adverse cardiovascular effects.
Tricyclic antidepressants
  • May potentiate the vascular effects of terbutaline.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Fox J G % Marini R P (2014) Eds. Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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