ISSN 2398-2985      

Propantheline

4ferrets

Introduction

Name

  • Propantheline bromide.

Class of drug

  • Quarternary ammonium antimuscarinic agent.

Description

Chemical name

  • methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium;bromide.

Molecular formula

  • C23H30BrNO3.

Molecular weight

  • 448.40.

Physical properties

  • Bitter-tasting, odorless, white or practically white crystals.
  • Very soluble in both water and alcohol. ​

Storage requirements

  • Store at room temperature in tight containers.

Uses

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Indications

  • Incontinence caused by detrusor hyperreflexia.
  • May occasionally be useful in treating bradycardias.
  • A peripherally acting anti-emetic (not recommended).
  • Occasionally used as an adjunctive therapy to treat diarrhea (but ileus is one side effect).

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antihistamines, benzodiazepines, pethidine, phenothiazines, procainamide and quinidine
  • May enhance the activity of propantheline and its derivatives.
Chronic corticosteroid use (may increase intra-ocular pressure), disopyramide, nitrates and primidone
  • May potentiate the adverse effects of propantheline and its derivatives.
Nitrofurantoin, sympathomimetics and thiazide diuretics
  • Propantheline and its derivatives may enhance the actions.
Metoclopropamide
  • Propantheline and its derivatives may antagonize the actions.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Johnson-Delaney C A (2017) Ferret Medicine and Surgery. CRC Press, USA. pp 514.
  •  Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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