ISSN 2398-2985      

Pimobendan

4ferrets

Synonym(s): Vetmedin, Cardisure, Acardi, Pimocard, Zelys


Introduction

Name

  • Pimobendan.

Class of drug

  • Inodilator.
  • Vasodilator.

Description

Chemical name

  • 4,5-dihydro-6-[2-(p-methyoxyphenyl)-5-benzimidazolyl]-5-methyl-3(2H-pyridazinone).

Molecular formula

  • C19H18N4O2.

Molecular weight

  • 334.37.

Physical properties

  • White or slightly yellowish hygroscopic powder.
  • Practically insoluble in water and slightly soluble in acetone or alcohol.

Storage requirements

  • Store in a dry place at room temperature.

Uses

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Indications

  • Off license use in ferrets used in combination drug therapy in the management of congestive heart failure due to dilated cardiomyopathy or mitral valve disease.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can be administered in combination with diuretics and angiotensin-converting enzyme (ACE) inhibitors.
  • Combination drug therapy using benazepril, furosemide and pimobendan may have hypotensive effects.
  • Anesthetics and sedative drugs may exacerbate hypotensive effects.
  • Use of verapamil or propranolol may reduce action of pimobendan.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Fox J G & Marini R P (2014) Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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