ISSN 2398-2985      

Omeprazole

4ferrets

Synonym(s): Prilosec


Introduction

Name

  • Omeprazole.

Class of drug

  • Proton pump inhibitor.

Description

Chemical name

  • 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole.

Molecular formula

  • C22H27ClO5.

Molecular weight

  • 406.90.

Storage requirements

  • Store at room temperature, in light resistant, tight containers.

Uses

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Indications

  • Used to treat and prevent gastritis and gastric ulcers.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Phenytoin and warfarin
  • Omeprazole may enhance the effects.
Benzodiazepines
  • Omeprazole may prolong CNS effects.
Cyclosporin
  • Omeprazole may reduce cyclosporine metabolism.
Drugs requiring decreased gastric pH for optimal absorption, eg ketoconazole, itraconazole, iron, ampicillin esters
  • Omeprazole may decrease drug absorption.
Sucralfate
  • May decrease bioavailability of orally administered omeprazole.

with diagnostic tests

  • May increase liver enzymes.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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