ISSN 2398-2985      

Leuprolide acetate

4ferrets

Synonym(s): Lupron depot


Introduction

Name

  • Leuperolide acetate.

Class of drug

  • Long-acting gonadotropin-releasing hormone analog.

Description

Chemical name

  • 5oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (salt).

Molecular formula

  • C61H88N16O14.

Molecular weight

  • 1269.47.

Physical properties

  • White to off-white powder.
  • Soluble in water (at least 250 mg are soluble in 1 mL of water).

Storage requirements

  • Store refrigerated and protected from light.
  • Not to be frozen according to manufacturer, but clinical use after freezing is common and appears to be effective.

Uses

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Indications

  • Adrenal disease.
  • Deslorelin Deslorelin implants are nowadays more commonly used than leuprolide acetate.

Administration

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Pharmacokinetics

Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Johnson-Delaney C A (2017) Ferret Medicine and Surgery. CRC Press, USA. pp 514.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Fox J G & Marini R P (2014) Eds Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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