ISSN 2398-2985      

Lactulose

4ferrets

Introduction

Name

  • Lactulose.

Class of drug

  • Disaccharide laxative.
  • Ammonia reducer.

Description

Chemical name

  • Galactose/fructose disaccharide.
  • (2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol.

Molecular formula

  • C12H22O11.

Molecular weight

  • 342.29.

Physical properties

  • White powder.
  • Very slightly soluble in alcohol and very soluble in water.

Storage requirements

  • Store in tight containers at room temperature.
  • Do not freeze.
  • If exposed to heat or light, darkening or cloudiness of the solution may occur, but apparently this does not affect drug potency.

Uses

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Indications

  • Reduce ammonia blood levels in the prevention and treatment of hepatic encephalopathy.
  • Safe and gentle osmotic laxative.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Oral antibiotics, eg neomycin
  • Synergy may occur.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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