ISSN 2398-2985      

Furosemide

4ferrets

Synonym(s): Frusemide, Lasix, Dimazon, Frusecare, Frusol, Frusedale, Disal, Furotabs, Furoject, Furocot


Introduction

Name

  • Furosemide.

Class of drug

  • Loop diuretic.

Description

Chemical name

  • 4-chloro-N-[2-furylmethyl]-5-sulfa-moylanthranilic acid.

Molecular formula

  • C12H11ClN2O5S.

Molecular weight

  • 330.74.

Physical properties

  • Odorless, practically tasteless, white to slightly yellow, fine, crystalline powder.
  • Practically insoluble in water, sparingly soluble in alcohol and freely soluble in alkaline hydroxides.

Storage requirements

  • Tablets: store in light-resistant, well-closed containers at room temperature.
  • Oral solution: room temperature and protected from light and freezing.
  • Injection: room temperature. A precipitate may form if the injection is refrigerated, but will resolve when warmed (it does not alter potency).

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Used in the management of:
    • Congestive cardiac failure.
    • Pulmonary edema.
    • Non-cardiogenic ascites or edema.
    • Hypercalciuric nephropathy.
    • Acute renal failure.
    • Hyperkalemia.
    • Hypertension.
    • Urolithiasis.

Congestive heart failure

  • There is evidence, although yet to be proven, that furosemide may acutely increase venous capacitance. This would be of benefit in the management of congestive cardiac failure.

The use of chronic diuretic monotherapy in the management of cardiac failure should be avoided, as patients receiving diuretics alone may deteriorate more rapidly than those receiving ACE inhibitors or digoxin Digoxin concurrently.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

  • If used concommitantly with corticosteroids or amphotericin B may increase the chance of hypokalemia.
  • Use with NSAIDs may predispose to nephrotoxicity, particularly in patients with poor renal perfusion.
ACE inhibitors and digoxin
  • Combination of furosemide, ACE inhibitor and digoxin with a sodium restricted diet may be associated with mild hyperkalemia.
Theophylline
  • May be enhanced when given with furosemide.
Aminoglycosides
  • Nephrotoxicity and ototoxicity associated with the aminoglycosides may be potentiated.
Digoxin
  • Furosemide may induce hypokalemia, thereby increasing the risk of digoxin toxicity.
Tubocurarine
  • May inhibit the muscle relaxation qualities.
Suxamethonium
  • Effects of suxamethonium may be increased.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook 8th edn. Wiley Blackwell. pp 1296.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code