ISSN 2398-2985      

Digoxin

4ferrets

Synonym(s): Lanoxin


Introduction

Name

  • Digoxin.

Class of drug

  • Cardiac glycoside.

Description

Chemical name

  • (3beta,5beta,12beta)-3-{[2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide.

Molecular formula

  • C41H64O14.

Molecular weight

  • 780.94.

Physical properties

  • Bitter tasting, clear to white, odorless crystalline powder.
  • Practically insoluble in water, slightly soluble in diluted alcohol and in chloroform, and very slightly soluble in 40% prolylene glycol.

Storage requirements

  • Room temperature and protected from light.

Uses

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Indications

  • Supraventricular tachycardia.
  • Congestive heart failure.
  • Dilated cardiomyopathy.
  • Mitral or tricuspid regurgitation.
  • Atrial fibrillation or flutter.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can be administered in combination with Angiotensin-converting enzyme (ACE) inhibitors.
  • Antacids and metoclopramide can reduce digoxin absorption from the gastrointestinal tract.
  • Diazepam, loop and thiazide diuretics, tetracycline, itraconazole, amphotericin B, glucocorticoids, anticholinergics and verapamil can increase serum digoxin levels, decrease elimination rate or enhance toxic side effects. Decrease dose and monitor digoxin serum levels and adjust accordingly.
  • Spironolactone may enhance or decrease the toxic effects of digoxin.
  • IV calcium, particularly fast administration, can produce serious arrythmias in patients on digoxin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Fox J G & Marini R P (2014) Eds Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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