ISSN 2398-2985      

Diazoxide

4ferrets

Synonym(s): Proglycem


Introduction

Name

  • Diazoxide.

Class of drug

  • Related to thiazide diuretics, but it does not possess any appreciable diuretic activity.

Description

Chemical name

  • 7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide.

Molecular formula

  • C8H7N2ClO2S.

Molecular weight

  • 230.66.

Physical properties

  • Odorless, white to creamy-white, crystalline powder.
  • It is practically insoluble to sparingly soluble in water and slightly soluble in alcohol

Storage requirements

  • Store at 2-30°C/35.6-86°F and protect from light.
  • Do not use darken solutions/suspensions, as they can be subpotent.

Uses

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Indications

  • Management of hypoglycemia caused by hyperinsulinism, eg insulinoma.
  • Insulinomas are common in ferrets.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Phenothiazines and thiazide diuretics
  • May increase the hyperglycemic activity of diazoxide.
Alpha-adrenergic blocking agents, eg phenoxybenzamine
  • Phenoxybenzamine may antagonize the effects of diazoxide.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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