ISSN 2398-2985      

Deslorelin

4ferrets

Synonym(s): Suprelorin


Introduction

Name

  • Deslorelin.
  • Available veterinary formulation contains deslorelin as deslorelin acetate.

Class of drug

  • Gonadotrophin-releasing hormone (GnRH) agonist.

Description

Chemical name

  • (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide.

Molecular formula

  • C64H83N17O12.

Molecular weight

  • 1282.45.

Physical properties

  • White to pale yellow cylindrical implant (size of a microchip).
  • Implant is supplied in a pre-loaded implanter.

Storage requirements

  • Store in refrigerator (2-8°C/35.6-46.4°F).
  • Do not freeze.
  • Shelf-life of product packaged for sale: 2 years.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Deslorelin implants have been researched with great extent in ferrets and their used is common for the prevention and treatment of a number of conditions.
  • As a general rule, it is used to prevent breeding, reduce aggression and reduce smell in males and to prevent breeding and prevent reproductive problems, eg hyperestrogenism, in females.
  • Also used for the treatment and prevention of adrenal disease.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

  • None known.
Warnings for personnel handling the product
  • Women in childbearing age should avoid contact with the product or wear disposable plastic gloves when handling the product.
  • ​Pregnant women should handle the product with extreme care.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • van Zeeland Y R A, Pabon M, Roest J et al (2014) Use of a GnRH agonist implant as alternative for surgical neutering in pet ferrets. Vet Rec 175 (3), 66 PubMed.
  • Bulliot C, Mentre V, Berthelet A et al (2014) Use of a Gonadotropin Releasing Hormone Agonist Implant Containing 4.7 mg Deslorelin for Medical Castration in Male Ferrets (Mustela putorius furo). Int J Appl Res Vet Med 12 (1), 67-75 VetMedResource.

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code