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Blood: biochemistry – lactate dehydrogenase
Synonym(s): LD, LDH, Serum LDH, SLDH
Overview
- Comprises 5 isoenzymes not organ specific, but useful in assessment of elevations in LDH in which the underlying cause is not apparent:
- LD1: heart muscle, brain, testes.
- LD2: smooth muscle, heart muscle, brain, kidney, bone and thymus.
- LD3: all major organs and smooth muscle.
- LD4: intestine, liver and skin.
- LD5: skeletal muscle, skin, liver and intestine. Isosenzyme modestly elevated with liver disease
and markedly raised with skeletal myopathy.
- Longer half-life than creatinine phosphokinase (CK or CPK) Blood: biochemistry - creatine kinase .
Uses
In combination
- With total LDH, LDH isoenzymes and/or other test results for evaluation of muscle damage or liver disease.
Sampling
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Tests
Methodologies
- Enzymatic method varies between laboratories (electrophoresis needed for LDH isoenymes).
Availability
- Limited availability.
Technique intrinsic limitations
- Test results most useful when interpreted in conjunction with other laboratory results and clinical findings.
Result Data
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
Other sources of information
- Kaneko J J, Harvey J W & Bruss M L (1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.
Organisation(s)
- Veterinary commercial laboratories, State diagnostic laboratories or Veterinary College laboratories.