Introduction

Name

• Ketoprofen.

Class of drug

• Non-steroidal anti-inflammatory.
• Analgesic.

Description

Chemical name

• (RS)2-(3-benzoylphenyl)-propionic acid.

Molecular formula

• C16H14O3.

Molecular weight

• 254.29.

Storage requirements

• Room temperature: 15-30°C/59-86°F.

Uses

Indications

• Inflammation.
• Pain associated with osteoarticular and musculoskeletal disorders (lameness, laminitis, osteoarthritis, synovitis, tendinitis, etc), post-operative pain and inflammation and visceral pain associated with colic.
• Pyrexia.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• Ketoprofen is highly bound to plasma proteins and may compete with other highly bound drugs which land lead to toxic effects.
• Concurrent administration of diuretics or potentially nephrotoxic drugs should be avoided since there is an increased risk of renal disturbances, including renal failure. This is secondary to the diminished blood flow caused by the inhibition of prostaglandins synthesis.
• Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, anticoagulants or diuretic concurrently or within 24 h of administration of the product since the risk of gastrointestinal ulceration and other adverse reactions may be exacerbated.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Brink P et al (1998) Stereospecific pharmacokinetics of free and protein-bound ketoprofen in serum and synovial fluid of horses after intravenous and intramuscular administration. Am J Vet Res 59 (6), 739-743 PubMed.
• Wilcke J R et al (1998) Pharmacokinetics of ketoprofen in healthy foals less than twenty-four hours old. Am J Vet Res 59 (3), 290-292 PubMed.
• Landoni M F & Lees P (1996) Pharmacokinetics and pharmacodynamics of ketoprofen enantiomers in the horse. J Vet Pharmacol Ther 19 (6), 466-474 PubMed.

Other sources of information

• Derived fromThe Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.