Introduction

Name

• Deslorelin.
• Available veterinary formulations contain deslorelin as deslorelin acetate:
  • Sterile suspension for horses (USA): each mL contains 1.8 mg deslorelin acetate (1.7 mg deslorelin) in sucrose acetate isobutyrate/propylene carbonate (70:30 wt:wt). Ten doses per vial.
  • Sterile implant for dogs and ferrets (UK and EU), containing 4.7 mg or 9.4 mg deslorelin acetate, in a preloaded applicator.

Class of drug

• Gonadotrophin-releasing hormone (GnRH) agonist.

Description

Chemical name

• (6-D-tryptophan-9-(N-ethyl-L-prolinamide)-10-deglycinamide) GnRH. 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucylL-arginyl-N-ethyl-L-prolinamide.

Molecular formula

• C₆₄H₈₃N₁₇O₁₂.

Molecular weight

• 1282.6 g/mol.

Physical properties

• Each mL Sucromate contains 1.8 mg deslorelin acetate (1.7 mg deslorelin) for injection as a sterile suspension in sucrose acetate isobutyrate/propylene carbonate (70:30 wt:wt).

Storage requirements

• Store in refrigerator at or below 8°C/46.4°F.
• Do not freeze.
• Shelf-life of product packaged for sale: 2 years.

Uses

Indications

• Induction of ovulation in cyclic estrous mares Female: hormonal therapy: induces ovulation within 48 h of treatment in 77% of mares with a developing follicle between 30 and 40 mm in diameter by increasing the levels of endogenous luteinizing hormone Therapeutics: reproductive system.
• Therapy with GnRH may be indicated where serial rectal palpations Urogenital: rectal palpation suggest that a previously maturing follicle has become arrested in its development (GnRH may be more successful than hCG in the induction of ovulation in such follicles, and also in large, thick-walled follicles).
• Has been effective in inducing ovulation within 48 h in mares showing characteristic signs of behavioral or physiologic estrus with follicles between 30 mm and 40 mm.

Administration

Pharmacokinetics

Precautions

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Kaps M, Okada C T C, Gautier C M et al (2021) Deslorelin slow-release implants delay ovulation and increase plasma AMH concentration and small antral follicles in Haflinger mares. Animals (Basel) 11 (6), 1600  PubMed.
• Kaps M, Okada C T C, Gautier C et al (2021) Transient suppression of ovulatory ovarian function in pony mares after treatment with slow-release deslorelin implants. Domest Anim Endocrinol 74, 106505 PubMed.
• Segabinazzi L G T M,  Oba E &  Alvarenga M A (2021) The combination of HCG and GnRH analog to hasten ovulation in mares does not change luteal function and pregnancy outcome in embryo recipient mares. J Equine Vet Sci  105, 103691  PubMed.
• Kwong G P S & Klein C (2019) Deslorelin and naltrexone stimulate follicular development in mares during autumn transition and early anestrus. Can Vet J 60 (8), 855-858 PubMed.
• Gautier C, Schmidt K, Aurich J & Aurich C (2018) Effects of implants containing the GnRH agonist deslorelin on testosterone release and semen characteristics in Shetland stallions. Anim Reprod Sci 195, 230-241  PubMed.
• Finan S A, Lamkin E L & McKinnon A O (2016) Comparative efficacy of BioRelease Deslorelin® injection for induction of ovulation in oestrus mares: a field study. Aust Vet J 94 (9), 338-340  PubMed.
• Hemberg E, Lundeheim M & Einarsson S (2006)  Successful timing of ovulation using Deslorelin (Ovuplant) is labour-saving in mares aimed for single Ai with frozen semen.  Repro Dom Anim  41  (6), 535-537 PubMed.
• Stich K L, Wendt K M, Blanchard T L & Brinsko S P (2004) Effects of a new injectable short-term release deslorelin in foal-heat mares. Theriogenol  62 (5), 831-836  PubMed.

Other sources of information

• Dechra Veterinary Products (2022) SucroMate Equine. Website: www.dechra-us.com (pdf download).
• European Medicines Agency (2020) Summary of Product Characteristics. Suprelorin 4.7 mg Implant for Dogs. Website: www.ema.europa.eu (pdf download).
• European Medicines Agency (2020) Suprelorin. Website: www.ema.europa.eu.
• European Medicines Agency (2002) Committee for Veterinary Medicinal Products. Deslorelin Acetate. Summary Report. Website: www.ema.europa.eu (pdf download).

Organisation(s)

• European Medicines Agency (EMA) Website: www.ema.europa.eu.
• National Office of Animal Health (NOAH)  Compendium of Data Sheets for Animal Medicines.  Website:  www.noahcompendium.co.uk.