Introduction

Name

• Cisplatin.

Class of drug

• Platinum compound antineoplastic agent Chemotherapy: general principles.
• Alkylating type agent.

Description

Chemical name

• (SP-4-2)-diamminedichloridoplatinum(II).

Molecular formula

• Cl₂H₆N₂Pt.

Molecular weight

• 300.05 g/mol.

Storage requirements

• 15-25°C/59-77°F.
• Do not refrigerate.
• Protect from light.

Uses

Indications

• Cell cycle non-specific antineoplastic agent, most commonly used as an intralesional treatment for nodular and/or fibroblastic sarcoids Sarcoid.
• Occasionally used for intralesional treatment of other masses such as melanomas Skin: neoplasia - melanoma, sarcomas, carcinomas Skin: neoplasia - squamous cell carcinoma.

Administration

Precautions

Interactions

With other drugs

• Aminoglycosides increase risk of nephrotoxicity, ototoxicity.

Adverse Reactions

Further Reading

Publications

Refereed Papers

• Recent references from PubMed and VetMedResource.
• Theon A P, Pascoe J R, Carlson G P & Krag D N (1993) Intratumoral chemotherapy with cisplatin in oily emulsion in horses. JAVMA 202 (2), 261-267 PubMed.

Other sources of information

• Theon A P, Galuppo L D, Snyder J R & Wilson W D (2006) Intratumoural administration of cisplatin for treatment of sarcoids in 378 horses. In: Proc AAEP Conference. Vol 52. pp 337-339.
• Goodrich L R & Semevolos S A (2000) How to prepare and inject cisplatin in oily emulsion to treat equine sarcoids and squamous cell carcinomas. In: Proc AAEP Conference. Vol 46. pp 173-175.