Introduction

Name

• Amphotericin B.

Class of drug

• Anti-fungal antibiotic; polyene.

Description

Molecular formula

• C₄₇H₇₃NO₁₇.

Physical properties

• Yellow powder/tablets or solution.

Storage requirements

• Loss of drug activity is negligible for at least 8 hours in room light.
• After reconstitution the preparation is stable for 1 week if refrigerated and stored in the dark.

Uses

Indications

Dogs and cats

• Serious systemic mycoses - yeast and fungal infections.
• Fungal septicemia.
• Fungal urinary tract infections.
• Intestinal candidiasis (man).
• Candida infections.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

Dogs and cats

• Do not use concurrently.

• Physically incompatible.

• May increase the toxic effects of cisplatin.

• May increase the toxic effects of fluorouracil.

• May increase the toxic effects of doxorubicin.

• May increase the toxic effects of methotrexate.

• Synergistic with amphotericin B in vitro against Candida spp Candida albicans, Cryptococcus spp Cryptococcus spp, Aspergillus spp Aspergillus spp.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• Derived from The Small Animal Formulary (1999) 3rd edn. Ed: Tennant B. British Small Animal Veterinary Association.
• Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.