ISSN 2398-2977      

Amikacin

pequis

Synonym(s): Amikacin sulfate


Introduction

Name

  • Amikacin.

Class of drug

Description

Chemical name

  • (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide.

Molecular formula

  • C22H43N5O13.

Molecular weight

  • 585.6.

Physical properties

  • White crystalline powder.

Storage requirements

  • Store at room temperature.
  • The solution becomes light straw-colored during storage, but this does not indicate a loss of potency.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Aminoglycosides are inactivated if combined in vitro with other drugs due to pH incompatibilities.
  • Synergistic against streptococci, Pseudomonas, and other Gram-negative bacteria if combined with ß-lactam antibiotics due to disruption of the bacterial cell wall by the ß-lactam antibiotic.
  • Neuromuscular blocking agents or drugs with neuromuscular blocking activity should not be used concurrently as they increase the risk of neuromuscular blockade, particularly during anesthesia.
  • Other nephrotoxic drugs should be avoided when possible during aminoglycoside therapy.
  • Nephrotoxicity and ototoxicity of aminoglycosides is potentiated by the loop diuretics furosemide and ethacrynic acid and probably other diuretic agents.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pezzanite L, Chow L, Hendrickson D et al (2021) Evaluation of intra-articular amikacin administration in an equine non-inflammatory joint model to identify effective bactericidal concentrations while minimizing cytotoxicity. Front Vet Sci 8, 676774 PubMed.
  • Dahan R, Oreff G L, Tatz A J et al (2019) Pharmacokinetics of regional limb perfusion using a combination of amikacin and penicillin in standing horses. Can Vet J 60, 294-299 PubMed.
  • Pinto N, Schumacher J, Taintor J, Degraves F, Duran S & Boothe D (2011) Pharmacokinetics of amikacin in plasma and selected body fluids of healthy horses after a single intravenous dose. Equine Vet J 43 (1), 112-116 PubMed
  • Magdesian K G et al (2004) Pharmacokinetics of a high dose of amikacin administered at extended intervals in neonatal foals. Am J Vet Res 65 (4), 473-479 PubMed.

Other sources of information

  • Plumb D C (2018) Plumb’s Veterinary Drug Handbook. Wiley Blackwell, USA. Online version: https://app.plumbs.com.
  • Cole C, Bentz B & Maxwell L (2014) Equine Pharmacology. Wiley Blackwell, USA.
  • Giguère S, Prescott J F & Dowling P M (2013) Eds Antimicrobial Therapy in Veterinary Medicine, 5th ed. Wiley Blackwell, USA.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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