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Hyperelastosis cutis

pequis

Synonym(s): Cutaneous asthenia, dermatoparaxis, Ehlers-Danlos syndrome, hereditary regional equine dermal asthenia (HERDA)


Introduction

  • Connective tissue disorder of skin.
  • Cause: autosomal, recessive mode of inheritance.
  • Signs: young animals (6 months to 2 years of age) presenting with increased incidence of injuries to skin of the body and limbs; soft, mushy areas of skin which range in size from several cm to the entire dorsum   Hyperelastosis cutis 01  , 'stretchy' skin   Hyperelastosis cutis 02  ; occasional hematomas, poor wound healing   Hyperelastosis cutis 03  .
  • Diagnosis: clinical evaluation, pedigree analysis, biopsy may be helpful.
  • Treatment: basic wound care; euthanasia in severe cases.
  • Prognosis: poor.

Pathogenesis

Etiology

  • Similar condition is seen in humans (Ehlers-Danlos Syndrome), mink, dogs, cats, cattle, sheep and pigs.
  • Inheritable condition in humans (autosomal dominant or recessive, X-linked recessive) and dogs, cats and mink (autosomal dominant).
  • Inherited in Quarterhorses as an autosomal recessive trait.
  • Traced to Poco Bueno and his immediate ancestors.

Pathophysiology

  • Connective tissue disorder of the skin.
  • Exact biochemical defect not yet confirmed in the horse.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Rendle D I, Durham A E & Smith K C (2008) Hereditary equine regional dermal asthenia in a quarter horse bred in the United Kingdom. Vet Rec 162 (1), 20-22 PubMed.
  • Rashmir-Raven A M & Winand N (unpublished data).
  • White S D, Affolter V K, Bannasch D Let al (2004) Hereditary equine regional dermal asthenia ('hyperelastosis cutis') in 50 horses: clinical, histological, immunohistological and ultrastructural findings. Vet Derm 15 (4), 207-217 PubMed.
  • Graves M, Rashmir-Raven A M & Black S S (2001) Clinical snapshot: Ehlers-Danlos like syndrome in a Quarterhorse gelding. Comp Contin Educ Pract Vet 23 (9), 827-837.
  • Brounts S, Rashmir-Raven A M & Black S S (2001) Zonal dermal separation: a distictive lesion associated with hyperelastosis cutis in a Quarter horse. Vet Derm 12, 219-224 PubMed.
  • Hardy M H et al (1988) An inherited connective tissue disease in the horse. Lab Invest 59, 259-262 PubMed.
  • Lerner D J & McCracken M D (1978) Hyperelastosis cutis in two horses. J Eq Med Surg 2, 350-352 VetMedResource.

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